Reference : Auditory Resting-State Network Connectivity in Tinnitus: a Functionnal MRI Study.
Scientific journals : Article
Human health sciences : Otolaryngology
http://hdl.handle.net/2268/126500
Auditory Resting-State Network Connectivity in Tinnitus: a Functionnal MRI Study.
English
MAUDOUX, Audrey [Centre Hospitalier Universitaire de Liège - CHU > > O.R.L. >]
LEFEBVRE, Philippe mailto [Centre Hospitalier Universitaire de Liège - CHU > > O.R.L. >]
CABAY, Jean-Evrard mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neuro-imagerie >]
Vanhaudenhuyse, Audrey mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Demertzi, Athina mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Laureys, Steven mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Soddu, Andrea mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
4-May-2012
PLoS ONE
Public Library of Science
Yes (verified by ORBi)
International
1932-6203
San Franscisco
CA
[en] Tinnitus ; fMRI ; Resting-state
[en] The underlying functional neuroanatomy of tinnitus remains poorly understood. Few studies have focused on functional cerebral connectivity changes in tinnitus patients. The aim of this study was to test if functional MRI ‘‘resting-state’’ connectivity patterns in auditory network differ between tinnitus patients and normal controls. Thirteen chronic tinnitus subjects and fifteen age-matched healthy controls were studied on a 3 tesla MRI. Connectivity was investigated using independent component analysis and an automated component selection approach taking into account the spatial and temporal properties of each component. Connectivity in extra-auditory regions such as brainstem, basal ganglia/NAc, cerebellum, parahippocampal, right prefrontal, parietal, and sensorimotor areas was found to be increased in tinnitus subjects. The right primary auditory cortex, left prefrontal, left fusiform gyrus, and bilateral occipital regions showed a decreased connectivity in tinnitus. These results show that there is a modification of cortical and subcortical functional connectivity in tinnitus encompassing attentional, mnemonic, and emotional networks. Our data corroborate the
hypothesized implication of non-auditory regions in tinnitus physiopathology and suggest that various regions of the brain seem involved in the persistent awareness of the phenomenon as well as in the development of the associated distress.
leading to disabling chronic tinnitus.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Tinnitus Prize 2011 (FNRS 9.4501.12)
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/2268/126500
http://www.plosone.org/article/info%3Adoi/10.1371/journal.pone.0036222#s5
http://reflexions.ulg.ac.be/acouphenescerveau

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