Reference : Le paradoxe des effets cutanes indesirables, mais predictifs de l'efficacite des therapi...
Scientific journals : Article
Human health sciences : Dermatology
http://hdl.handle.net/2268/12649
Le paradoxe des effets cutanes indesirables, mais predictifs de l'efficacite des therapies ciblees anticancereuses.
French
[en] Cutaneous adverse effects predicting the efficacy of targeted antineoplastic therapies
Quatresooz, Pascale mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Rorive, Andrée mailto [Centre Hospitalier Universitaire de Liège - CHU > > Oncologie médicale >]
Paquet, Philippe mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Pierard, Claudine [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Pierard, Gérald mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
2009
Revue Médicale de Liège
Hopital de Baviere
64
5-6
347-50
Yes (verified by ORBi)
National
0370-629X
Liège
Belgique
[en] Antibodies, Monoclonal/administration & dosage/adverse effects ; Antineoplastic Agents/administration & dosage/adverse effects ; Drug Eruptions/etiology ; Humans ; Neoplasms/drug therapy ; Receptor, Epidermal Growth Factor/antagonists & inhibitors
[en] A series of medical disciplines benefit from the emergence of diverse targeted therapies using monoclonal antibodies. Skin is affected by adverse events of such therapies primarily targeting internal cancers. As a unique event in medicine, some of the skin adverse effects are predictive markers of the therapeutic antineoplastic activity. This fact concerns the paroxismal acneiform eruption and the inflammatory flare-up of actinic keratoses. Such a situation is linked to the fact that these specific "unwanted" effects are not really side effects but rather represent the direct pharmacological consequence of the activity directed to the EGF receptors which are particularly abundant in the follicular ostium and in precursor lesions to skin carcinomas.
http://hdl.handle.net/2268/12649

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
PARADOXE.pdfPublisher postprint313.76 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.