Reference : Synthesis of two new alkyne-bearing liners used for the preparation of siRNA for labe...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/126475
Synthesis of two new alkyne-bearing liners used for the preparation of siRNA for labeling by click chemistry with fluorine-18
English
[fr] Synthèse de deux linkers, porteurs d'un groupe alcyne, utilisés pour la preparation de siRNA pour le marquage au fluor-18 par chimie click.
Flagothier, Jessica mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse >]
Kaisin, Geoffroy mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Mercier, Frederic mailto [> >]
Thonon, David mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Teller, Nathalie mailto [> >]
Wouters, Johan mailto [> >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse >]
Aug-2012
Applied Radiation & Isotopes
Pergamon Press
70
8
1549-1557
Yes (verified by ORBi)
International
0969-8043
Oxford
United Kingdom
[en] fluorine-18 ; click chemistry ; siRNA
[en] Oligonucleotides (ONs) and more particularly siRNAs are promising drugs but their pharmacokinetics and biodistribution are widely unknown. Positron Emission Tomography (PET) using fluorine-18 is a suitable technique to quantify these biological processes. Click chemistry (Huisgen cycloaddition) is the current method for labeling siRNA. In order to study the influence of a linker bearing by [18F]labeled ONs, on the in vivo pharmacokinetic and metabolism, we have developed two modified ONs by two news linkers. Here we report the synthesis of two alkyne-bearing linkers, the incorporation onto a ONs and the conjugation by click chemistry with a [18F]prosthetic group.
Centre de Recherches du Cyclotron - CRC
Région wallone
OligoPET
Researchers ; Professionals
http://hdl.handle.net/2268/126475

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