Reference : Soluble HLA-G in IVF/ICSI embryo culture supernatants does not always predict implantati...
Scientific journals : Article
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
http://hdl.handle.net/2268/12643
Soluble HLA-G in IVF/ICSI embryo culture supernatants does not always predict implantation success: a multicentre study.
English
Tabiasco, J. [ > > ]
PERRIER d'HAUTERIVE, Sophie [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
Thonon, Fabienne [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
Parinaud, J. [ > > ]
Léandri, R. [ > > ]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
Chaouat, G. [ > > ]
Munaut, Carine mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Lombroso, R. [ > > ]
Selva, J. [ > > ]
Bergère, M. [ > > ]
Hammoud, I. [ > > ]
Kozma, N. [ > > ]
Aguerre-Girr, M. [ > > ]
Swales, A. K. [ > > ]
Sargent, I. L. [ > > ]
Le Bouteiller, P. [ > > ]
Lédée, Nathalie [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
2009
Reproductive Biomedicine Online
Reproductive BioMedicine Online
18
3
374-81
Yes (verified by ORBi)
1472-6483
1472-6491
Cambridge
United Kingdom
[en] embryo transfer ; ICSI ; IVF ; soluble HLA-G
[en] Several reports have described an association between the presence of soluble human leukocyte antigen G (sHLA-G) in human embryo culture supernatants (ES) and implantation success. However, not all studies agree with these findings. To further document this debate, a multicentre blinded study was performed to investigate, on a large number of IVF ES and ICSI ES, whether sHLA-G is a useful criterion for embryo selection before transfer. A total of 1405 ES from 355 patients were collected from three assisted reproductive technique (ART) centres and evaluated for their sHLA-G content in a single laboratory, using a chemiluminescence enzyme-linked immunosorbent assay. In only one centre was a significant association between sHLA-G-positive ES and successful implantation established (P = 0.0379), whereas no such association was observed in the other centres. It was found that the percentages and concentrations of sHLA-G-positive ES varied between centres, depending on culture media and ART conditions. The percentage of sHLA-G-positive ES was significantly higher in IVF ES than ICSI ES (P < 0.001 and P < 0.01 for two centres). These data demonstrate that substantial variations of sHLA-G content in ES occur between different ART centres, highlighting the influence of several technical parameters that differ from one centre to another.
http://hdl.handle.net/2268/12643

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Tabiasco, Le Bouteiller-RBM-2009.pdfPublisher postprint456.78 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.