Reference : Galectin-1 in Melanoma Biology and Related Neo-Angiogenesis Processes.
Scientific journals : Article
Human health sciences : Oncology
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/126335
Galectin-1 in Melanoma Biology and Related Neo-Angiogenesis Processes.
English
Mathieu, V. [> >]
de Lassalle, Elisabeth Martin []
Toelen, J. [> >]
Mohr, T. [> >]
Bellahcene, Akeila mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R : Labo de recherche sur les métastases >]
Van, Goietsenoven [> >]
Verschuere, T. [> >]
Bouzin, C. [> >]
Debyser, Z. [> >]
De Vleesschouwer, Steven []
Van Gool, Stefaan []
Poirier, Françoise [> >]
Castronovo, Vincenzo mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire >]
Kiss, Robert [> >]
Feron, Olivier [> >]
2012
Journal of Investigative Dermatology
Nature Publishing Group
Yes (verified by ORBi)
International
0022-202X
1523-1747
New York
NY
[en] Aggressiveness of advanced melanomas relates in part to their marked propensity to develop neoangiogenesis and metastases. Among its numerous pro-cancer roles, galectin (gal)-1 expressed and/or secreted by both cancer and endothelial cells stimulates proliferation and angiogenesis. This study first shows that gal-1 is more highly expressed at both mRNA and protein levels than its congeners in melanomas and particularly in advanced lesions. The roles of gal-1 were further investigated in vivo in the highly proliferating and vascularized pseudometastatic B16F10 mouse melanoma model using stable knockdown B16F10 cells and wild-type versus gal-1 knockout mice, and then in vitro in B16F10 tumoral and lung microvascular cells. Gal-1 depletion in the B16F10 tumor cells but not in the tumor-bearing mice significantly increased melanoma-bearing mice survival. Tumor-derived gal-1 thus seems to have more critical roles than the host-derived one. In fact, gal-1 displays distinct effects on the H-Ras-dependent p53/p21 pathways: in primary lung microvessel endothelial cells, gal-1 seems to be involved in the maintenance of senescent status through the induction of both p53 and p21 while it stimulates B16F10 cancer cell proliferation through a p53/p21 decrease. Altogether, these data point to gal-1 as a potential target to combat melanomas.Journal of Investigative Dermatology advance online publication, 24 May 2012; doi:10.1038/jid.2012.142.
Giga-Cancer
Fonds Yvonne Boël ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
http://hdl.handle.net/2268/126335
10.1038/jid.2012.142

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