ORBi: Le Dinh Hieu - Results of kidney transplantation from controlled donors after cardio-circulatory death: a single center experience

Reference : Results of kidney transplantation from controlled donors after cardio-circulatory death:...


	Document type :	Scientific congresses and symposiums : Paper published in a journal
	Discipline(s) :	Human health sciences : Surgery
	To cite this reference:	http://hdl.handle.net/2268/126043

Title :	Results of kidney transplantation from controlled donors after cardio-circulatory death: a single center experience
Language :	English
Author, co-author :	Le Dinh, Hieu [Université de Liège - ULg > > > Doct. sc. médicales (Bologne)]
	WEEKERS, Laurent [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
	BONVOISIN, Catherine [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
	KRZESINSKI, Jean-Marie [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
	MONARD, Josée [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
	DE ROOVER, Arnaud [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
	DETRY, Olivier [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
	SQUIFFLET, Jean-Paul [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
	MEURISSE, Michel [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Publication date :	May-2012
Journal title :	Acta Chirurgica Belgica
Publisher :	Acta Medica Belgica
Volume :	112
Issue/season :	3
Pages :	66.FP7.
On invitation :	No
Audience :	National
ISSN :	0001-5458
City :	Bruxelles
Country :	Belgique
Event name :	Thirteenth Belgian Surgical Week
Event date :	du 9 au 12 mai 2012
Event organizer :	Royal Belgian Society for Surgery
Event place (city) :	Spa
Event country :	Belgium
Abstract :	[en] Objectives: The aim of this study was to determine results of kidney transplantation (KT) from controlled donation after cardio-circulatory death (DCD). Primary end-points were graft and patient survival, and post-transplant complications. The inﬂuence of delayed graft function (DGF) on graft survival and DGF risk factors were analyzed as secondary end-points. Methods: This is a retrospective mono-center review of a consecutive series of 80 DCD-KT performed at the University Hospital of Sart Tilman, University of Liège, between Jan 2005 and Dec 2011. Mean patient follow-up was 28.5 months. Results: Overall graft survival was 93.7%, 89.5%, 85% and 81.3% at 3 months, 1 year, 3 and 5 years, respectively. Death-censored graft survival at the corresponding time points was 93.7%, 93.7%, 90.8% and 90.8%. Main cause of graft loss was patient’s death with a functioning graft. No primary non-function grafts were encountered. Renal graft function was suboptimal at hospital discharge, but nearly normalized at 3 months. DGF was observed in 36% of all DCD-KT. DGF signiﬁcantly increased post-operative length of hospitalization, but had no deleterious impact on graft function or survival. Donor body mass index (BMI) ≥30 kg/m2, recipient BMI ≥30 kg/m2 and pre-transplant dialysis duration signiﬁcantly increased the risk of DGF in a multivariate logistic regression analysis (p < 0.05). Conclusions: Despite a higher rate of DGF, controlled DCD-KT offers a valuable contribution to the pool of deceased donor kidney grafts, with comparable mid-term results to those procured after brain death.
Permalink :	http://hdl.handle.net/2268/126043

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