Reference : Results of kidney transplantation from controlled donors after cardio-circulatory dea...
Scientific congresses and symposiums : Paper published in a journal
Human health sciences : Surgery
http://hdl.handle.net/2268/126043
Results of kidney transplantation from controlled donors after cardio-circulatory death: a single center experience
English
Le Dinh, Hieu mailto [Université de Liège - ULg > > > Doct. sc. médicales (Bologne)]
WEEKERS, Laurent mailto [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
BONVOISIN, Catherine mailto [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
KRZESINSKI, Jean-Marie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
MONARD, Josée mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
DE ROOVER, Arnaud mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
DETRY, Olivier mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
SQUIFFLET, Jean-Paul mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
MEURISSE, Michel mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
May-2012
Acta Chirurgica Belgica
Acta Medica Belgica
112
3
66.FP7.
Yes (verified by ORBi)
No
National
0001-5458
Bruxelles
Belgique
Thirteenth Belgian Surgical Week
du 9 au 12 mai 2012
Royal Belgian Society for Surgery
Spa
Belgium
[en] Objectives: The aim of this study was to determine results of kidney transplantation (KT) from controlled donation after cardio-circulatory death (DCD). Primary end-points were graft and patient survival, and post-transplant complications. The influence of delayed graft function (DGF) on graft survival and DGF risk factors were analyzed as secondary end-points.

Methods: This is a retrospective mono-center review of a consecutive series of 80 DCD-KT performed at the University Hospital of Sart Tilman, University of Liège, between Jan 2005 and Dec 2011. Mean patient follow-up was 28.5 months.

Results: Overall graft survival was 93.7%, 89.5%, 85% and 81.3% at 3 months, 1 year, 3 and 5 years, respectively. Death-censored graft survival at the corresponding time points was 93.7%, 93.7%, 90.8% and 90.8%. Main cause of graft loss was patient’s death with a functioning graft. No primary non-function grafts were encountered. Renal graft function was suboptimal at hospital discharge, but nearly normalized at 3 months. DGF was observed in 36% of all DCD-KT. DGF significantly increased post-operative length of hospitalization, but had no deleterious impact on graft function or survival. Donor body mass index (BMI) ≥30 kg/m2, recipient BMI ≥30 kg/m2 and pre-transplant dialysis duration significantly increased the risk of DGF in a multivariate logistic regression analysis (p < 0.05).

Conclusions: Despite a higher rate of DGF, controlled DCD-KT offers a valuable contribution to the pool of deceased donor kidney grafts, with comparable mid-term results to those procured after brain death.
http://hdl.handle.net/2268/126043

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