Reference : Gene transfer in inner ear cells: a challenging race
Scientific journals : Article
Human health sciences : Otolaryngology
http://hdl.handle.net/2268/126030
Gene transfer in inner ear cells: a challenging race
English
Sacheli, Rosalie mailto [> >]
Delacroix, Laurence mailto [Université de Liège - ULg > Département des sciences cliniques > GIGA-R: Neurosciences > >]
Van Den Ackerveken, Priscilla mailto [Université de Liège - ULg > > GIGA - Neurosciences >]
Nguyen, Laurent mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Malgrange, Brigitte mailto [Université de Liège - ULg > > GIGA - Neurosciences >]
2013
Gene Therapy
Nature Publishing Group
20
Yes (verified by ORBi)
International
0969-7128
1476-5462
London
United Kingdom
[en] gene delivery ; inner ear ; therapy
[en] Recent advances in human genomics led to the identification of numerous defective genes causing deafness, which represent novel putative therapeutic targets. Future gene-based treatment of deafness resulting from genetic or acquired sensorineural hearing loss may include strategies ranging from gene therapy to antisense delivery. For successful development of gene therapies, a minimal requirement involves the engineering of appropriate gene carrier systems. Transfer of exogenous genetic material into the mammalian inner ear using viral or non-viral vectors has been characterized over the last decade. The nature of inner ear cells targeted, as well as the transgene expression level and duration, are highly dependent on the vector type, the route of administration and the strength of the promoter driving expression. This review summarizes and discusses recent advances in inner ear gene-transfer technologies aimed at examining gene function or identifying new treatment for inner ear disorders.
Researchers
http://hdl.handle.net/2268/126030
10.1038/gt.2012.51

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