Article (Scientific journals)
Miconazole , a pharmacological barrier to skin fungal infections.
Pierard, Gérald; Hermanns-Lê, Trinh; Delvenne, Philippe et al.
2012In Expert Opinion on Pharmacotherapy, 13 (8), p. 1187-94
Peer Reviewed verified by ORBi
 

Files


Full Text
Pierard 2012 miconazole.pdf
Publisher postprint (719.23 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Introduction: Miconazole (MCZ) is a time-honored antifungal of the imidazole class. MCZ exerts a multipronged effect on fungi. It inhibits the cytochrome P450 complex, including the 14alpha-demethylase enzyme required for ergosterol biosynthesis, in fungal cell membranes. In addition, intracellular accumulation of toxic methylated sterols occurs and the synthesis of triglycerides and phospholipids is altered. Disturbances in oxidative and peroxidative enzyme activities lead to an intracellular toxic concentration of hydrogen peroxide. As a result, intracellular organelle destruction then leads to cell necrosis. Farnesol synthesis stimulated in Candida spp. prevents the yeast-to-mycelium formation. MCZ is further active against Gram-positive bacteria. Areas covered: This review aims at revisiting the MCZ antifungal activity in dermatomycoses. Expert opinion: MCZ's wide spectrum of activity appears noteworthy. The full pharmacological profile of MCZ indicates its fungistatic profile through its effect on ergosterol biosynthesis. In addition, it exhibits a fungicidal effect against a number of fungal species, due to hydrogen peroxide accumulation. MCZ is characterized by high safety, efficacy and versatility, and a unique, multifaceted nature of activity in the treatment of dermatomycoses.
Disciplines :
Dermatology
Author, co-author :
Pierard, Gérald ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Hermanns-Lê, Trinh ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Delvenne, Philippe ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Franchimont, Claudine ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Language :
English
Title :
Miconazole , a pharmacological barrier to skin fungal infections.
Publication date :
2012
Journal title :
Expert Opinion on Pharmacotherapy
ISSN :
1465-6566
eISSN :
1744-7666
Publisher :
Ashley Publications Ltd, London, United Kingdom
Volume :
13
Issue :
8
Pages :
1187-94
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 May 2012

Statistics


Number of views
158 (8 by ULiège)
Number of downloads
2 (0 by ULiège)

Scopus citations®
 
33
Scopus citations®
without self-citations
33
OpenCitations
 
25

Bibliography


Similar publications



Contact ORBi