Reference : Differential Effects of Cocaine on Dopamine Neuron Firing in Awake and Anesthetized Rats
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/125860
Differential Effects of Cocaine on Dopamine Neuron Firing in Awake and Anesthetized Rats
English
Koulchitsky, Stanislav mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie >]
DE BACKER, Benjamin mailto [Université de Liège - ULg > Département de Pharmacie > Chimie toxicologique > >]
Quertemont, Etienne mailto [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Psychologie quantitative >]
Charlier, Corinne mailto [Université de Liège - ULg > Département de pharmacie > Chimie toxicologique >]
Seutin, Vincent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie >]
2012
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Nature Publishing Group
37
1559-1571
Yes (verified by ORBi)
International
0893-133X
London
United Kingdom
[en] Cocaine (benzoylmethylecgonine), a natural alkaloid, is a powerful psychostimulant and a highly addictive drug. Unfortunately, the relationships between its behavioral and electrophysiological effects are not clear. We investigated the effects of cocaine on the firing of midbrain dopaminergic (DA) neurons, both in anesthetized and awake rats, using pre-implanted multielectrode arrays and a recently developed telemetric recording system. In anesthetized animals, cocaine (10 mg/kg, intraperitoneally) produced a general decrease of the firing rate and bursting of DA neurons, sometimes preceded by a transient increase in both parameters, as previously reported by others. In awake rats, however, injection of cocaine led to a very different pattern of changes in firing. A decrease in firing rate and bursting was observed in only 14% of DA neurons. Most of the other DA neurons underwent increases in firing rate and bursting: these changes were correlated with locomotor activity in 52% of the neurons, but were uncorrelated in 29% of them. Drug concentration measurements indicated that the observed differences between the two conditions did not have a pharmacokinetic origin. Taken together, our results demonstrate that cocaine injection differentially affects the electrical activity of DA neurons in awake and anesthetized states. The observed increases in neuronal activity may in part reflect the cocaine-induced synaptic potentiation found ex vivo in these neurons. Our observations also show that electrophysiological recordings in awake animals can uncover drug effects, which are masked by general anesthesia.
http://hdl.handle.net/2268/125860
10.1038/npp.2011.339
http://www.nature.com/npp/journal/vaop/ncurrent/full/npp2011339a.html
http://www.nature.com

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