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Article (Scientific journals)
Pharma-clinics le medicament du mois. L'orlistat (xenical).
Scheen, André; Ernest, Philippe; Letiexhe, Michel
1999In Revue Médicale de Liège, 54 (3), p. 192-6
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Keywords :
Dietary Fats/metabolism; Enzyme Inhibitors/administration & dosage/pharmacology/therapeutic use; Humans; Hypercholesterolemia/drug therapy; Lactones/administration & dosage/pharmacology/therapeutic use; Obesity/drug therapy; Weight Loss
Abstract :
[en] Orlistat (tetrahydrolipstatin), launched by Roche under the trade name Xenical, is a selective inhibitor of pancreatic and gastro-intestinal lipases. It reduces the digestion of dietary fat and its resorption through digestive mucosa by around 30%. It is indicated, at a dose of 3 x 120 mg/day (one dose with each meal) and together with a moderately low-calorie and low-fat diet, for the treatment of obesity. It has been shown, in placebo-controlled two-year trials, to almost double the number of obese subjects who succeed in loosing at least 10% of initial body weight. Independently, it contributes to decrease serum cholesterol levels by 6-10%. Because of its mechanism of action, this drug can induce intestinal side-effects which tend to decrease with time and with the reduction of fat intake, thus improving diet compliance.
Disciplines :
Pharmacy, pharmacology & toxicology
Endocrinology, metabolism & nutrition
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Ernest, Philippe ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Letiexhe, Michel ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Language :
French
Title :
Pharma-clinics le medicament du mois. L'orlistat (xenical).
Alternative titles :
[fr] Pharmacy-clinics medication of the month. Orlistate (xenical)
Publication date :
1999
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Hopital de Baviere, Liège, Belgium
Volume :
54
Issue :
3
Pages :
192-6
Peer reviewed :
Peer reviewed
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