No full text
Article (Scientific journals)
L'etude clinique du mois. L'etude CAPPP: "The Captopril Prevention Project".
Scheen, André
1999In Revue Médicale de Liège, 54 (3), p. 197-9
Peer reviewed
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Adrenergic beta-Antagonists/therapeutic use; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors/pharmacology/therapeutic use; Captopril/pharmacology/therapeutic use; Cardiovascular Diseases/drug therapy/mortality/prevention & control; Cerebrovascular Disorders; Diabetes Mellitus/prevention & control; Diuretics/therapeutic use; Female; Humans; Hypertension/complications/drug therapy; Male; Middle Aged; Treatment Outcome
Abstract :
[en] The Captopril Prevention Project (CAPPP) was a prospective, randomized, open trial which aimed at comparing the prevention by captopril (n = 5492) or by a conventional treatment (n = 5493; diuretics or beta-blockers) of cardiovascular morbidity and mortality in patients with hypertension (diastolic blood pressure > 100 mmHg). After a mean follow-up of 6.1 years, the results regarding the primary endpoint and most secondary endpoints were not significantly different between the two therapeutic modalities. The only differences (perhaps due to a randomisation bias) were a slightly higher incidence of stroke, but a lower risk of diabetes mellitus, in the captopril group than in the group receiving conventional treatment. In conclusion, the CAPPP study demonstrates, for the first time, that captopril, an angiotensin-converting-enzyme inhibitor, is as effective as conventional treatment with diuretics or beta-blockers, two drugs whose efficacy has already been demonstrated when compared to placebo, in the prevention of cardiovascular morbidity and mortality in hypertensive patients.
Disciplines :
Pharmacy, pharmacology & toxicology
Cardiovascular & respiratory systems
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
L'etude clinique du mois. L'etude CAPPP: "The Captopril Prevention Project".
Alternative titles :
[fr] Clinical study of the month. The CAPPP study: "The Captopril Prevention Project"
Publication date :
1999
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Hopital de Baviere, Liège, Belgium
Volume :
54
Issue :
3
Pages :
197-9
Peer reviewed :
Peer reviewed
Available on ORBi :
since 08 May 2009

Statistics


Number of views
89 (0 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
6
Scopus citations®
without self-citations
5

Bibliography


Similar publications



Contact ORBi