Reference : Occurrence of cardiovascular calcifications in normal, aging rats.
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/125708
Occurrence of cardiovascular calcifications in normal, aging rats.
English
Roosens, B [> > > >]
Bala, G [> > > >]
Droogmans, S [> > > >]
Hostens, J [> > > >]
Somja, Joan mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques]
Delvenne, E [> > > >]
Schiettecatte, J [> > > >]
Delvenne, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques]
Lahoutte, T [> > > >]
Van Camp, G [> > > >]
Cosyns, B [> > > >]
2012
Experimental Gerontology
Elsevier Science
47
8
614-9
Yes (verified by ORBi)
International
0531-5565
Tarrytown
NY
[en] BACKGROUND: Cardiovascular calcification is an independent predictor of morbidity and mortality and increases with age. Animal models are frequently used to investigate the underlying pathophysiology. Only scarce data regarding the effect of aging on calcifications in these animal models are available. The aim of this study is to investigate the occurrence of cardiovascular calcifications in normal, aging rats. METHODS: A mixed inbred/outbred population of 44 male Lewis/Wistar rats was studied. Group 1 of three-month-old rats, group 2 twelve-month-old, group 3 twenty-four-month-old and group 4 thirty-month-old rats. Calibrated integrated backscatter (cIB) values and blood parameters (creatinine, parathyroid hormone (PTH)) were measured, followed by ex-vivo micro-CT and histology as reference methods. RESULTS: Cardiovascular calcifications developed with age, as demonstrated by significantly increasing cIB values of the aortic valve and myocardium. This was confirmed by a significant increase in the calcified volume on ex-vivo micro-CT and in the histological calcium score. There was also a significantly higher level of creatinine and PTH with age. CONCLUSIONS: As in humans, cardiovascular calcifications progressively increase with age in the normal rat. Therefore the aging rat model could be used for studying calcifying cardiovascular disease. cIB might have a value in future studies for the early detection of subclinical calcifications in humans.
http://hdl.handle.net/2268/125708
10.1016/j.exger.2012.05.012
Copyright (c) 2012. Published by Elsevier Inc.

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