Reference : Local applications of GM-CSF induce the recruitment of immune cells in cervical low-grad...
Scientific journals : Article
Human health sciences : Oncology
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/1257
Local applications of GM-CSF induce the recruitment of immune cells in cervical low-grade squamous intraepithelial lesions.
English
Hubert, Pascale mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Doyen, Jean [Université de Liège - ULg > > Gynécologie-Obstétrique CHR >]
Capelle, Xavier mailto [Université de Liège - ULg > > Gynécologie-Obstétrique >]
Arafa, M. [> >]
Renoux, Virginie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Bisig, Bettina mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Seidel, Laurence mailto [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique >]
Evrard, Brigitte mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique >]
Bousarghin, Latifa [> >]
Gerday, Colette [Université de Liège - ULg > > Gynécologie-Obstétrique CHR >]
Boniver, Jacques mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
Delvenne, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Jacobs, Nathalie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
2010
American Journal of Reproductive Immunology
Blackwell
64
2
126-136
Yes (verified by ORBi)
International
1046-7408
Oxford
United Kingdom
[en] Clinical trial ; immunotherapy ; GM-CSF ; Human papillomavirus ; uterine cervical cancer ; adaptive immune response
[en] Abstract
Problem
Quantitative alterations of antigen-presenting cells (APC) in (pre)neoplastic lesions of the uterine cervix associated with human papillomavirus (HPV) infection suggest a diminished capacity to capture viral antigens and to induce a protective immune response.
Method of study
To test if a cervical application of GM-CSF could restore an immune response against HPV in women with cervical low-grade squamous intraepithelial lesions (LSIL). We performed two clinical trials with11 healthy women and 15 patients with LSIL.
Results
GM-CSF applications were well tolerated in all enrolled women and no difference in toxicity between the treated and placebo groups was observed during the follow up (until 30 months). Interestingly, in the GM-CSF treated group, a significant increased APC and cytotoxic T lymphocyte infiltration was observed in the cervical biopsies with no change in regulatory T cell numbers. All the HPV16+ patients exhibited an immune response against HPV16 after GM-CSF applications, as shown by NK and/or T cells producing IFN-γ whereas no cellular immune response was observed before the treatment. Moreover, the anti-VLP antibody titers also increased after the treatment.
Conclusion
These encouraging results obtained from a limited number of subjects justify further study on the therapeutic effect of APC in cervical (pre)neoplastic lesions.
Giga-Infection, Immunity and Inflammation ; Giga-Cancer
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Marshall Program of the Walloon Region ; Fonds Léon Fredericq
Colvir (Grant from Walloon Region)
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/1257
10.1111/j.1600-0897.2010.00834.x
The definitive version is available at www3.interscience.wiley.com

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
GM-CSF AJRI.pdfAuthor preprint192.05 kBView/Open
Open access
Figure GM-CSF.pdfAuthor preprint671.54 kBView/Open
Open access
Table 1GM-CSF.pdfAuthor preprint46.3 kBView/Open
Restricted access
Hubert2010American journal of reproductive immunology (New York NY 1989).pdfPublisher postprint385.72 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.