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Local applications of GM-CSF induce the recruitment of immune cells in cervical low-grade squamous intraepithelial lesions.
Hubert, Pascale; Doyen, Jean; Capelle, Xavier et al.
2010In American Journal of Reproductive Immunology, 64 (2), p. 126-136
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Keywords :
Clinical trial; immunotherapy; GM-CSF; Human papillomavirus; uterine cervical cancer; adaptive immune response
Abstract :
[en] Abstract Problem Quantitative alterations of antigen-presenting cells (APC) in (pre)neoplastic lesions of the uterine cervix associated with human papillomavirus (HPV) infection suggest a diminished capacity to capture viral antigens and to induce a protective immune response. Method of study To test if a cervical application of GM-CSF could restore an immune response against HPV in women with cervical low-grade squamous intraepithelial lesions (LSIL). We performed two clinical trials with11 healthy women and 15 patients with LSIL. Results GM-CSF applications were well tolerated in all enrolled women and no difference in toxicity between the treated and placebo groups was observed during the follow up (until 30 months). Interestingly, in the GM-CSF treated group, a significant increased APC and cytotoxic T lymphocyte infiltration was observed in the cervical biopsies with no change in regulatory T cell numbers. All the HPV16+ patients exhibited an immune response against HPV16 after GM-CSF applications, as shown by NK and/or T cells producing IFN-γ whereas no cellular immune response was observed before the treatment. Moreover, the anti-VLP antibody titers also increased after the treatment. Conclusion These encouraging results obtained from a limited number of subjects justify further study on the therapeutic effect of APC in cervical (pre)neoplastic lesions.
Research center :
GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège
Giga-Cancer - ULiège
Disciplines :
Oncology
Immunology & infectious disease
Author, co-author :
Hubert, Pascale  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Doyen, Jean ;  Université de Liège - ULiège > Gynécologie-Obstétrique CHR
Capelle, Xavier ;  Université de Liège - ULiège > Gynécologie-Obstétrique
Arafa, M.
Renoux, Virginie ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Bisig, Bettina ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Seidel, Laurence  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
Evrard, Brigitte  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Bousarghin, Latifa
Gerday, Colette ;  Université de Liège - ULiège > Gynécologie-Obstétrique CHR
Boniver, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement
Delvenne, Philippe ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Jacobs, Nathalie  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
More authors (4 more) Less
Language :
English
Title :
Local applications of GM-CSF induce the recruitment of immune cells in cervical low-grade squamous intraepithelial lesions.
Publication date :
2010
Journal title :
American Journal of Reproductive Immunology
ISSN :
1046-7408
eISSN :
1600-0897
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
64
Issue :
2
Pages :
126-136
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Colvir (Grant from Walloon Region)
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Marshall Program of the Walloon Region
Fonds Léon Fredericq [BE]
Available on ORBi :
since 16 February 2010

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