Abstract :
[en] The relationship between sunlight exposure and
the incidence of multiple sclerosis and the understanding of
immunomodulatory effects of vitamin D triggered, in recent
years, a broad range of investigations. Immunological studies
performed in vitro and in vivo have demonstrated how tolerogenic
vitamin D can be. Epidemiological studies confirmed an
increased incidence of multiple sclerosis in vitamin D deficient
subjects and signs of increased disease activity in such MS
patients. Although small-scale observational studies have suggested
a beneficial impact of vitamin D supplementation on the
incidence and severity of multiple sclerosis, large scale clinical
trials remain warranted to confirm these preliminary results.
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