Reference : Relating the Chondrocyte Gene Network to Growth Plate Morphology: From Genes to Phenotype
Scientific journals : Article
Engineering, computing & technology : Multidisciplinary, general & others
http://hdl.handle.net/2268/125273
Relating the Chondrocyte Gene Network to Growth Plate Morphology: From Genes to Phenotype
English
Kerkhofs, Johan mailto [Université de Liège - ULg > > > Form. doct. sc. ingé. (aérosp. & méca - Bologne)]
Roberts, Scott J mailto [> >]
Luyten, Frank P mailto [> >]
Van Oosterwyck, Hans mailto [> >]
Geris, Liesbet mailto [Université de Liège - ULg > Département d'aérospatiale et mécanique > Génie biomécanique >]
30-Apr-2012
PLoS ONE
Public Library of Science
Yes (verified by ORBi)
International
1932-6203
San Franscisco
CA
[en] tissue engineering ; logical modelling ; chondrocyte ; growth plate ; chondrocytes ; gene network ; differentiation ; signalling ; endochondral ossification ; ossification ; genes ; model
[en] During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-scale literature based logical model of the growth plate network was developed. The network is able to capture the different states (resting, proliferating and hypertrophic) that chondrocytes go through as they progress within the growth plate. In a first corroboration step, the effect of mutations in various signalling pathways of the growth plate network was investigated.
Biomechanics research unit
FRS.D-10/20
Researchers
http://hdl.handle.net/2268/125273
10.1371/journal.pone.0034729

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