Reference : Thymus and type 1 diabetes: An update
Scientific journals : Article
Human health sciences : Immunology & infectious disease
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/125114
Thymus and type 1 diabetes: An update
English
Geenen, Vincent mailto [Université de Liège - ULg > > Centre d'immunologie >]
2012
Diabetes Research & Clinical Practice
Elsevier Scientific
Yes (verified by ORBi)
International
0168-8227
1872-8227
Limerick
Ireland
[en] Thymus ; Self-tolerance ; Autoimmunity ; Type 1 diabetes ; Insulin family ; AIRE ; Coxsackievirus B4
[en] Type 1 diabetes (T1D) is a chronic disease resulting from the selective autoimmune
destruction of pancreatic islet ß cells. The absence and/or breakdown of immune selftolerance
to islet ß cells is now recognized as the essential cause for the development of the
diabetogenic autoimmune response. For a long time, a failure in peripheral tolerogenic
mechanisms was regarded as the main source of an inappropriate immune process directed
against insulin-secreting ß cells. While defective peripheral self-tolerance still deserves to
be further investigated, the demonstration that all members of the insulin gene family are
transcribed in thymic epithelial cells (TECs) of different species under the control of the
AutoImmune REgulator (AIRE) gene/protein has highlighted the importance of central self-tolerance to insulin-secreting islet b cells. Moreover, there is now evidence that a primary or acquired failure in thymus-dependent central self-tolerance to ß cells plays a primary role in T1D pathogenesis. This novel knowledge is currently translated into the development of
innovative tolerogenic/regulatory approaches designed to reprogram the specific immune
self-tolerance to islet ß cells.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE ; Union Européenne = European Union - UE = EU (FP6)
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/125114
http://dx.doi.org/10.1016/ j.diabres.2012.05.023

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