Article (Scientific journals)
The Effect of Nasal hCT on Bone Turnover in Paget's Disease of Bone--Implications for the Treatment of Other Metabolic Bone Diseases
Reginster, Jean-Yves; JEUGMANS, Anne-Marie; Franssen, Marcelle et al.
1992In British Journal of Rheumatology, 31 (1), p. 35-9
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Abstract :
[en] Thirty pagetic patients were treated for 6 months with a daily nasal application of 2 mg of synthetic human calcitonin (hCT). Serum alkaline phosphatases (SAP) and urinary hydroxyproline/creatinine ratio (OH/Cr), reflecting bone turnover, were significantly reduced from the first month of treatment (mean +/- SEM: SAP, -13.9 +/- 2.2%; OH/Cr, -22.2 +/- 5.8%; both P less than 0.01) and until the end of the 6-month course (mean +/- SEM: SAP, -29.7 +/- 4.6%; OH/Cr, -22.5 +/- 5.9%; both P less than 0.01). Nasal hCT was perfectly tolerated both locally and systemically. These results allow us to consider nasal hCT for long-term trials in metabolic bone diseases characterized by a relative increase of bone resorption.
Disciplines :
Rheumatology
Author, co-author :
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
JEUGMANS, Anne-Marie 
Franssen, Marcelle ;  Centre Hospitalier Universitaire de Liège - CHU > HOSPITALISATION - UNITE STERILE ( SI -3C)
Sarlet, Nathalie ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur
McIntyre, Harold David
Franchimont, Paul
Language :
English
Title :
The Effect of Nasal hCT on Bone Turnover in Paget's Disease of Bone--Implications for the Treatment of Other Metabolic Bone Diseases
Publication date :
January 1992
Journal title :
British Journal of Rheumatology
ISSN :
0263-7103
Publisher :
Oxford University Press, United Kingdom
Volume :
31
Issue :
1
Pages :
35-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 June 2012

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