Reference : The Effect of Nasal hCT on Bone Turnover in Paget's Disease of Bone--Implications for...
Scientific journals : Article
Human health sciences : Rheumatology
http://hdl.handle.net/2268/125034
The Effect of Nasal hCT on Bone Turnover in Paget's Disease of Bone--Implications for the Treatment of Other Metabolic Bone Diseases
English
Reginster, Jean-Yves mailto [Université de Liège - ULg > Département des sciences de la santé publique > Epidémiologie et santé publique >]
Jeugmans-Huynen, A. M. [> > > >]
Franssen, Marcelle [Centre Hospitalier Universitaire de Liège - CHU > > HOSPITALISATION - UNITE STERILE ( SI -3C) >]
Sarlet, Nathalie [Centre Hospitalier Universitaire de Liège - CHU > > Médecine de l'appareil locomoteur >]
McIntyre, H. D. [> > > >]
Franchimont, P. [> > > >]
Jan-1992
British Journal of Rheumatology
31
1
35-9
Yes (verified by ORBi)
International
0263-7103
[en] Thirty pagetic patients were treated for 6 months with a daily nasal application of 2 mg of synthetic human calcitonin (hCT). Serum alkaline phosphatases (SAP) and urinary hydroxyproline/creatinine ratio (OH/Cr), reflecting bone turnover, were significantly reduced from the first month of treatment (mean +/- SEM: SAP, -13.9 +/- 2.2%; OH/Cr, -22.2 +/- 5.8%; both P less than 0.01) and until the end of the 6-month course (mean +/- SEM: SAP, -29.7 +/- 4.6%; OH/Cr, -22.5 +/- 5.9%; both P less than 0.01). Nasal hCT was perfectly tolerated both locally and systemically. These results allow us to consider nasal hCT for long-term trials in metabolic bone diseases characterized by a relative increase of bone resorption.
http://hdl.handle.net/2268/125034

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