|Reference : Successful treatment of equine sarcoids with cisplatin electrochemotherapy: a retrospect...|
|Scientific journals : Article|
|Life sciences : Veterinary medicine & animal health|
|Successful treatment of equine sarcoids with cisplatin electrochemotherapy: a retrospective study of 48 cases.|
|Tamzali, Y [Université de Toulouse, INP, ENVT, Toulouse, France > > > >]|
|Borde, Laura [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Médecine interne des équidés >]|
|Rols, MP [IPBS, UMR 5089, CNRS and University of Toulouse, Toulouse, France. > > > >]|
|Golzio, M [IPBS, UMR 5089, CNRS and University of Toulouse, Toulouse, France. > > > >]|
|Lyazrhi, F [Université de Toulouse, INP, ENVT, Toulouse, France > > > >]|
|Teissie, J [IPBS, UMR 5089, CNRS and University of Toulouse, Toulouse, France. > > > >]|
|Equine Veterinary Journal|
|Equine Veterinary Journal Ltd|
|[en] REASONS FOR PERFORMING STUDY: Sarcoids are the commonest form of equine skin tumour. Several therapeutic measures have been described but none is considered to be universally effective. Electrochemotherapy (ECT) is a new anticancer therapy that utilises electrical field pulses to induce increased cell membrane permeability to antitumour hydrophilic drugs, such as cisplatin. The increased intracellular concentration of the drugs has a significant therapeutic benefit. The procedure has not been previously reported in a large number of horses.
OBJECTIVE: To validate ECT as a novel alternative treatment for equine sarcoids.
METHODS: A retrospective study evaluating the efficacy of cisplatin ECT in the treatment of equine sarcoids was performed. Electrochemotherapy treatments were applied under general anaesthesia at 2 week intervals with or without prior excision or debulking. Electric pulses were directly applied to the lesions following intra-tumoural injections of an aqueous solution of cisplatin.
RESULTS: One-hundred-and-ninety-four sarcoids on 34 horses, 2 ponies, 11 donkeys and one mule were treated with ECT. The 4 year nonrecurrence rate was 97.9% for animals (47/48) and 99.5% (193/194) for tumours. When ECT was used as a single treatment, a significant influence of tumour size (ρ= 0.55) on the number of treatments required for cure was shown. When prior surgery was performed, there was a significant influence (P<0.001) of the excision quality (complete or incomplete) and the healing mode (closed or open wound) on the number of treatments. The most common adverse effect was a slight oedematous reaction for lesions located on thin skin regions.
CONCLUSION AND CLINICAL RELEVANCE: Results demonstrate that ECT, with or without concurrent tumour debulking, is an effective alternative for treatment of equine sarcoids
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