Reference : L'hyperglycemie post-prandiale. I. Physiopathologie, consequences cliniques et approa...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/12482
L'hyperglycemie post-prandiale. I. Physiopathologie, consequences cliniques et approaches dietetiques.
French
[en] Postprandial hyperglycemia. I. Physiopathology, clinical consequences and dietary management
Scheen, André mailto [Université de Liège - ULg > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale >]
Paquot, Nicolas mailto [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques >]
Jandrain, Bernard [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques >]
Lefebvre, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques >]
2002
Revue Médicale de Liège
57
3
138-41
Yes (verified by ORBi)
0370-629X
Belgium
[en] Absorption ; Cardiovascular Diseases ; Diabetes Complications ; Dietary Carbohydrates/metabolism ; Dietary Fiber ; Glucagon/metabolism ; Humans ; Hyperglycemia/diet therapy/drug therapy/physiopathology ; Hypoglycemic Agents/pharmacology ; Insulin/pharmacology ; Kinetics ; Postprandial Period ; Risk Factors
[en] Postprandial hyperglycaemia depends on the amount and type of ingested carbohydrates and/or the degree of inhibition of hepatic glucose output following a meal. The kinetics of carbohydrate absorption is directly influenced by the type of food (carbohydrates with variable glycaemic indices, fibre content of the meal) and by the speed of gastric emptying. Hepatic glucose output is remarkably inhibited by insulin and strongly stimulated by glucagon. It remains abnormally high after a meal in diabetic patients because of insufficient portal insulin concentrations, hepatic insulin resistance and/or hyperglucagonaemia. In diabetic patients, postprandial hyperglycaemia contributes to the aggravation of chronic hyperglycaemia, and thus to the increase of glycated haemoglobin levels. Furthermore, it has been recently demonstrated that postprandial hyperglycaemia increases the cardiovascular risk, even in nondiabetic subjects, probably by inducing endothelial dysfunction. Appropriate dietary counselling plays a key-role in the control of postprandial hyperglycaemia. Generally speaking, it includes a selection of carbohydrates with low glycaemic index and a higher fibre intake. Pharmacological interventions may also be considered when necessary.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/12482
http://www.rmlg.ulg.ac.be

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