Reference : Tridentate N-Donor Palladium(II) Complexes as Efficient Coordinating Quadruplex DNA Bind...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/124620
Tridentate N-Donor Palladium(II) Complexes as Efficient Coordinating Quadruplex DNA Binders
English
Largy, Eric [> > > >]
Hamon, Florian [> > > >]
Rosu, Frédéric [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)]
Gabelica, Valérie mailto [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)]
De Pauw, Edwin mailto [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)]
Guedin, Aurore [> > > >]
Mergny, Jean*-Louis [> > > >]
Teulade-Fichou, Marie*-Paule [> > > >]
2011
Chemistry : A European Journal
Wiley
17
47
13274-13283
Yes (verified by ORBi)
International
0947-6539
1521-3765
[en] DNA ; FRET ; G-quadruplexes ; mass spectrometry ; transition metals
[en] Fifteen complexes of palladium, platinum, and copper, featuring five different N-donor tridentate (terpyridine-like) ligands, were prepared with the aim of testing their G-quadruplexDNA binding properties. The fluorescence resonance energy transfer melting assay indicated a striking positive effect of palladium on G-quadruplex DNA stabilization compared with platinum and copper, as well as an influence of the structure of the organic ligand. Putative binding modes (noncoordinative p stacking and base coordination) of palladium and platinum complexes were investigated by ESI-MS and UV/Vis spectroscopy experiments, which all revealed a greater ability of palladium complexes to coordinate DNA bases. In contrast, platinum compounds tend to predominantly bind to quadruplex DNA in their aqua form by noncoordinative interactions. Remarkably, complexes of [Pd(ttpy)] and [Pd(tMebip)] (ttpy=tolylterpyridine, tMebip=2,2'-(4-p-tolylpyridine-2,6-diyl)bis(1-methyl-1H-benzo[d]imidazole)) coordinate efficiently G-quadruplex structures at room temperature in less than 1 h, and are more efficient than their platinum counterparts for inhibiting the growth of cancer cells. Altogether, these results demonstrate that both the affinity for G-quadruplex DNA and the binding mode of metal complexes can be modulated by modifying either the metal or the organic ligand.
http://hdl.handle.net/2268/124620
10.1002/chem.201102300

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
2011-Chem. Eur. J. 2011-17-13274-Hig_res_Pt-Pd-Teulade-Fichou.pdfPublisher postprint2.97 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.