Reference : Stabilization of gold nanoparticles by thermo-responsive poly (vinyl alcohol)-b-poly (N-...
Scientific congresses and symposiums : Poster
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/124414
Stabilization of gold nanoparticles by thermo-responsive poly (vinyl alcohol)-b-poly (N-vinylcaprolactam) copolymers
English
Liu, Ji [Institut de Chimie de la Matière Consensée de Bordeaux and University of Liège (ULg) > Department of Chemistry of Liège > Center for Education and Research on Macromolecules (CERM, Liège) > >]
Hurtgen, Marie [University of Liège (ULg) > Department of Chemistry > The "IDS-FUNMAT" erasums-mundus program > >]
Detrembleur, Christophe mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Mornet, Stephan [Institut de Chimie de la Matière Consensée de Bordeaux > > > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Duguet, Etienne [Institut de Chimie de la Matière Consensée de Bordeaux > > > >]
21-Nov-2011
No
No
National
PAI P6/27 Annual Meeting
21/11/2011 - 22/11/2011
Leuven
Belgium
[en] radical polymerization ; cobalt-mediated radical polymerization (CMRP) ; metal nanoparticle ; stimuli-responsive polymer ; temperature-responsive polymer
[en] Stimuli-responsive nano-materials have been playing increasingly important roles in the biomedical field due to their ability to alter the physico-chemical properties in response to external stimuli, such as temperature, pH, ionic strength, magnetic field, etc. Nanohybrids bearing an inorganic core and thermo-responsive polymer shell are particularly applicable in target delivery and controlled drug release. Poly (N-vinylcaprolactam) (PNVCL) and its copolymers, exhibiting lower critical solution temperature (LCST) where the transition between hydrophilic and hydrophobic state happens, is one of the optimal choices for this core/shell structure. Here we present the in-situ fabrication of thermo-responsive gold nanohybrids coated with a novel poly(vinyl alcohol)-b-poly(N-vinylcaprolactam) (PVOH-b-PNVCL) block copolymer prepared by the cobalt-mediated radical polymerization (CMRP). The interaction between both PVOH and PNVCL segments and gold nanoparticles was confirmed by FT-IR spectra. A sharp thermo-induced phase transition with a good reversibility upon change in temperature was detected by DLS and UV/vis spectrometer. Furthermore, the presence of hydrophilic PVOH moieties endows the gold nanohybrids with improved colloidal stability above LCST without any flocculation detected, compared with the gold nanoparticles stabilized with PNVCL homopolymer. This kind of gold nanohybrids can be envisaged as a new drug delivery vehicle.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; The "IDS-FUNMAT" erasums-mundus program
Researchers
http://hdl.handle.net/2268/124414
This poster was presented by Ji Liu

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