Reference : Magnetic hybrid materials for triggered drug delivery and optical properties of intra...
Scientific congresses and symposiums : Poster
Engineering, computing & technology : Materials science & engineering
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/124408
Magnetic hybrid materials for triggered drug delivery and optical properties of intraocular lens
English
Liu, Ji [University of Liège (ULg) and Institut de Chimie de la Matière Consensée de Bordeaux > Department of Chemistry (Liège) > Center for Education and Research on Macromolecules (CERM, Liège) > >]
Hurtgen, Marie [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Mornet, Stephan [Institut de Chimie de la Matière Consensée de Bordeaux > > > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Duguet, Etienne [Institut de Chimie de la Matière Condensée de Bordeaux > > > >]
30-Mar-2012
No
No
The International Doctoral School in Functional Materials (IDS-FunMat) Training School
24/03/2012- 30/03/2012
The University of Bordeaux
Anglet
France
[en] radical polymerization ; cobalt-mediated radical polymerization (CMRP) ; metal nanoparticle ; stimuli-responsive polymer ; temperature-responsive polymer
[en] Stimuli-responsive nano-materials have been playing increasingly important roles in the biomedical field due to their ability to alter the physico-chemical properties in response to external stimuli, such as temperature, pH, ionic strength, magnetic field, etc. Nanohybrids bearing an inorganic core and thermo-responsive polymer shell are particularly applicable in target delivery and controlled drug release. Poly (N-vinylcaprolactam) (PNVCL) and its copolymers, exhibiting lower critical solution temperature (LCST) where the transition between hydrophilic and hydrophobic state happens, is one of the optimal choices for this core/shell structure. Here we present the in-situ fabrication of thermo-responsive gold nanohybrids coated with a novel poly (vinyl alcohol)-b-poly (N-vinylcaprolactam) (PVOH-b-PNVCL) block copolymers, which were prepared by the cobalt-mediated radical polymerization (CMRP). The interaction between both PVOH and PNVCL segments and gold nanoparticles was confirmed by FT-IR spectra. A sharp thermo-induced phase transition with a good reversibility upon change in temperature was detected by DLS and UV/vis spectrometer. Furthermore, the presence of hydrophilic PVOH moieties endows the gold nanohybrids with improved colloidal stability above LCST without any flocculation detected. This kind of gold nanohybrids can be envisaged as a new drug delivery vehicle.
Center for Education and Research on Macromolecules (CERM)
the Erasmus-Mundus "IDS-FUNMAT" program
Researchers
http://hdl.handle.net/2268/124408
This poster was presented by Ji Liu

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