ORBi: Liu Ji - Stimuli-responsive magnetic nanohybrids designed for controlled drug release application

Reference : Stimuli-responsive magnetic nanohybrids designed for controlled drug release application


	Document type :	Scientific congresses and symposiums : Unpublished conference
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry Engineering, computing & technology : Materials science & engineering
	To cite this reference:	http://hdl.handle.net/2268/124398

Title :	Stimuli-responsive magnetic nanohybrids designed for controlled drug release application
Language :	English
Author, co-author :	Liu, Ji [University of Liège (ULg) and Institut de Chimie de la Matière Condensée de Bordeaux > Department of Chemistry (Liège) > Center for Education and Research on Macromolecules (CERM, Liège) > > >]
	Detrembleur, Christophe [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Mornet, Stephan [Institut de Chimie de la Matière Condensée de Bordeaux > > > >]
	Jérôme, Christine [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Duguet, Etienne [Institut de Chimie de la Matière Condensée de Bordeaux > > > >]
Publication date :	10-May-2012
On invitation :	No
Event name :	Belgian Polymer Group (BPG) annual meeting 2012
Event date :	10/05/2012 - 11/05/2012
Event organizer :	KUL
	DSM
Event place (city) :	Blankenberge
Event country :	Belgium
Keywords :	[en] biomaterial ; nanostructured materials ; metal nanoparticle ; stimuli-responsive polymer ; pH-sensitive polymer ; nanomedicine
Abstract :	[en] Stimuli-responsive organic/inorganic nanohybrids, with an inorganic core and a polymer coating, have been frequently suggested as a promising vehicle for drug or gene delivery and also controlled release, due to their outstanding biocompatibility, versatile surface modification, specific responsive properties to external stimuli, and so on. Magnetic nanoparticles have various applications in biomedical filed, such as magnetic resonance imaging, biosensors, magnetic separation, drug release, hyperthermia therapy and so on. Poly (acrylic acid) copolymers exhibit a sharp conformation transition when exposed to external change in pH. The PAA copolymer was used to form a polymer shell outside the magnetic core, a cationic dye was uploaded by electro-static interaction. The controlled release was achieved by tuning the external pH value. Magnetic/SiO2 mesoporous nanoparticles were prepared as another drug vehicle, in order to obtain a higher drug loading amount. Crystalline molecules were utilized as a gate keeper to control the release of drugs uploaded.
Research units :	Center for Education and Research on Macromolecules (CERM)
Funders :	The IDS-FUNMAT doctoral school
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/124398
Commentary :	This oral communication was presented by Ji Liu

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