ORBi: Pottel Hans - Demystifying ethnic/sex differences in kidney function: is the difference in (estimating) glomerular filtration rate or in serum creatinine concentration?

Reference : Demystifying ethnic/sex differences in kidney function: is the difference in (estimating...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Urology & nephrology Human health sciences : Laboratory medicine & medical technology
	To cite this reference:	http://hdl.handle.net/2268/123926

Title :	Demystifying ethnic/sex differences in kidney function: is the difference in (estimating) glomerular filtration rate or in serum creatinine concentration?
Language :	English
Author, co-author :	Pottel, Hans [> >]
	Hoste, Liesbeth [> >]
	DELANAYE, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
	CAVALIER, Etienne [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
	Martens, Frank [> >]
Publication date :	Oct-2012
Journal title :	Clinica Chimica Acta
Publisher :	Elsevier Science
Volume :	413
Issue/season :	19-20
Pages :	1612-17
Audience :	International
ISSN :	0009-8981
City :	Amsterdam
Country :	The Netherlands
Keywords :	[en] Estimating glomerular filtration rate ; serum creatinine ; race ; gender
Abstract :	[en] BACKGROUND: The recent evaluation of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimating the glomerular filtration rate (GFR) in multiple ethnicities has raised the question on how well this equation performs for African-American and Asian subjects. There is no doubt that serum creatinine (Scr) concentration differs between ethnicities and sexes. We show that creatinine-based equations for white populations may be inaccurate for estimating GFR in other ethnic/gender groups, especially in populations from Asia. METHODS: This study presents a mathematical analysis of the CKD-EPI-equation complemented with a literature review of median and reference values for IDMS-standardized Scr-concentrations for multiple ethnicities. RESULTS: The study shows that at equal eGFR-CKD-EPI-values, the ratio of Scr between females and males equals 0.79 and between other ethnicities/sexes and white males is constant too. From this information, it is possible to calculate mean Scr-values that correspond very well with literature values directly obtained from Scr-distributions in healthy white males and females and in black males, but the discrepancy is larger for other populations. CONCLUSIONS: Our results confirm the criticism that has been raised for using the CKD-EPI-equation for these ethnicities. An alternative eGFR-model is proposed based on a population-normalized Scr that needs further validation.
Permalink :	http://hdl.handle.net/2268/123926

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