Article (Scientific journals)
Intensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma
Tilly, Hervé; Lepage, Eric; Coiffier, Bertrand et al.
2003In Blood, 102 (13), p. 4284-4289
Peer Reviewed verified by ORBi
 

Files


Full Text
200.pdf
Publisher postprint (243.99 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) in previously untreated patients with poor-risk aggressive lymphoma. Patients aged 61 to 69 years who had aggressive non-Hodgkin lymphoma with at least one prognostic factor of the age-adjusted international prognostic index (IPI) were included. ACVBP consisted of an induction phase of intensified chemotherapy and central nervous system (CNS) prophylaxis followed by a sequential consolidation phase. Of the 708 patients registered for the study, 635 were eligible. The rate of complete response was 58% in the ACVBP group and 56% in the CHOP group (P =.5). Treatment-related death occurred in 13% of the ACVBP group and 7% of the CHOP group (P =.014). At 5 years, the event-free survival was 39% in the ACVBP group and 29% in the CHOP group (P =.005). The overall survival was significantly longer for patients treated with ACVBP, at 5 years it was 46% compared with 38% for patients treated with CHOP (P =.036). CNS progressions or relapses were more frequent in the CHOP group (P =.004). Despite higher toxicity, the ACVBP regimen, used as first-line treatment for patients with poor-risk aggressive lymphoma, is superior to standard CHOP with regard to both event-free survival and overall survival. (C) 2003 by The American Society of Hematology.
Disciplines :
Hematology
Author, co-author :
Tilly, Hervé
Lepage, Eric
Coiffier, Bertrand
Blanc, Michel
Herbrecht, Raoul
Bosly, André
Attal, Michel
Fillet, Georges ;  Université de Liège - ULiège > Département des sciences cliniques > Hématologie - Oncologie médicale
Guettier, Catherine
Jo Molina, Thierry
Gisselbrecht, Christian
Reyes, Félix
Language :
English
Title :
Intensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma
Publication date :
2003
Journal title :
Blood
ISSN :
0006-4971
eISSN :
1528-0020
Publisher :
American Society of Hematology, Washington, United States - District of Columbia
Volume :
102
Issue :
13
Pages :
4284-4289
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 31 March 2009

Statistics


Number of views
232 (0 by ULiège)
Number of downloads
902 (0 by ULiège)

Scopus citations®
 
293
Scopus citations®
without self-citations
236
OpenCitations
 
249

Bibliography


Similar publications



Contact ORBi