Reference : Hepatic insulin resistance in obese non-diabetic subjects and in type 2 diabetic patients.
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/12357
Hepatic insulin resistance in obese non-diabetic subjects and in type 2 diabetic patients.
English
Paquot, Nicolas mailto [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques >]
Scheen, André mailto [Université de Liège - ULg > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale >]
Dirlewanger, Mirjam [> > > >]
Lefebvre, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques >]
Tappy, Luc [> > > >]
2002
Obesity Research
North American Association for the Study of Obesity (NAASO)
10
3
129-34
Yes (verified by ORBi)
International
1071-7323
1550-8528
Silver Spring
MD
[en] Adult ; Aged ; Blood Glucose/analysis ; Diabetes Mellitus/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Fatty Acids, Nonesterified/blood ; Female ; Glucagon/blood ; Humans ; Insulin/blood/pharmacology ; Insulin Resistance/physiology ; Liver/physiopathology ; Male ; Middle Aged ; Obesity/metabolism ; Somatostatin/pharmacology
[en] OBJECTIVE: Obese non-diabetic patients are characterized by an extra-hepatic insulin resistance. Whether obese patients also have decreased hepatic insulin sensitivity remains controversial. RESEARCH METHODS AND PROCEDURES: To estimate their hepatic insulin sensitivity, we measured the rate of exogenous insulin infusion required to maintain mildly elevated glycemia in obese patients with type 2 diabetes, obese non-diabetic patients, and lean control subjects during constant infusions of somatostatin and physiological low-glucagon replacement infusions. To account for differences in insulin concentrations among the three groups of subjects, an additional protocol was also performed in healthy lean subjects with higher insulin infusion rates and exogenous dextrose infusion. RESULTS: The insulin infusion rate required to maintain glycemia at 8.5 mM was increased 4-fold in obese patients with type 2 diabetes and 1.5-fold in obese non-diabetic patients. The net endogenous glucose production (measured with 6,6-(2)H(2)-glucose) and total glucose output (measured with 2-(2)H(1)-glucose) were approximately 30% lower in the patients than in the lean subjects. Net endogenous glucose production and total glucose output were both markedly increased in both groups of obese patients compared with lean control subjects during hyperinsulinemia. DISCUSSION: Our data indicate that both obese non-diabetic and obese type 2 diabetic patients have a blunted suppressive action of insulin on glucose production, indicating hepatic and renal insulin resistance.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/12357
10.1038/oby.2002.21

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