ORBi: Noël Agnès - Membrane associated proteases and their inhibitors in tumour angiogenesis

Reference : Membrane associated proteases and their inhibitors in tumour angiogenesis


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/12353

Title :	Membrane associated proteases and their inhibitors in tumour angiogenesis
Language :	English
Author, co-author :	Noël, Agnès [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
	Maillard, Catherine [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Rocks, Natacha [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Jost, M. [> > > >]
	Chabottaux, Vincent [ > > ]
	Sounni, Nor Eddine [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Maquoi, Erik [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Cataldo, Didier [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement - Département des sciences biomédicales et précliniques]
	Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
Publication date :	Jun-2004
Journal title :	Journal of Clinical Pathology
Publisher :	BMJ Group
Volume :	57
Issue/season :	6
Pages :	577-584
Audience :	International
ISSN :	0021-9746
e-ISSN :	1472-4146
Keywords :	[en] membrane-type matrix metalloproteinases ; tumoral angiogenesis ; serine proteases ; a disintegrin and metalloproteinase ; protease inhibitors
Abstract :	[en] Cell surface proteolysis is an important mechanism for generating biologically active proteins that mediate a range of cellular functions and contribute to biological processes such as angiogenesis. Although most studies have focused on the plasminogen system and matrix metalloproteinases ( MMPs), recently there has been an increase in the identification of membrane associated proteases, including serine proteases, ADAMs, and membrane-type MMPs (MT-MMPs). Normally, protease activity is tightly controlled by tissue inhibitors of MMPs (TIMPs) and plasminogen activator inhibitors (PAIs). The balance between active proteases and inhibitors is thought to determine the occurrence of proteolysis in vivo. High concentrations of proteolytic system components correlate with poor prognosis in many cancers. Paradoxically, high (not low) PAI-1 or TIMP concentrations predict poor survival in patients with various cancers. Recent observations indicate a much more complex role for protease inhibitors in tumour progression and angiogenesis than initially expected. As knowledge in the field of protease biology has improved, the unforeseen complexities of cell associated enzymes and their interaction with physiological inhibitors have emerged, often revealing unexpected mechanisms of action.
Permalink :	http://hdl.handle.net/2268/12353
DOI :	10.1136/jcp.2003.014472

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Open access	Noel A JCP 2004.pdf.pdf		Author postprint	410.13 kB	View/Open

All documents in ORBi are protected by a user license.

Dspace v1.5