Article (Scientific journals)
Effects of a progestogen on normal human breast epithelial cell apoptosis in vitro and in vivo
Desreux, Joëlle; Kebers, F.; Noël, Agnès et al.
2003In Breast, 12 (2), p. 142-149
Peer reviewed
 

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Keywords :
normal breast; fibroadenoma; breast cancer; apoptosis; progestogen; nomegestrol acetate
Abstract :
[en] Many investigators have reported cyclic proliferation of normal human breast epithelial cells. A delicate balance between proliferation and apoptosis (programmed cell death) ensures breast homeostasis. Both the follicular and luteal phases of the menstrual cycle are characterized by proliferation, whereas apoptosis occurs only at the end of the latter phase. In this study, we observed that the withdrawal of a synthetic progestin (nomegestrol acetate or NOMAC), but not continuous treatment with it, induced apoptosis of normal human breast epithelial cells in vitro and in women who applied NOMAC gel to their breasts. Furthermore, this apoptotic response was specific to normal breast cells, since withdrawal of NOMAC did not induce apoptosis of tumoral T47D cells in vitro or of fibroadenoma cells in women. These observations open up new perspectives in the prevention of hyperplasia and breast cancer. (C) 2003 Elsevier Science Ltd. All rights reserved.
Disciplines :
Oncology
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Desreux, Joëlle ;  Centre Hospitalier Universitaire de Liège - CHU > Sénologie
Kebers, F.
Noël, Agnès ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme
Francart, D.
Van Cauwenberge, H.
HEINEN, Vincent 
Peyrollier, K.
Thomas, J. L.
Bernard, A. M.
Paris, J.
Delansorne, R.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Language :
English
Title :
Effects of a progestogen on normal human breast epithelial cell apoptosis in vitro and in vivo
Publication date :
April 2003
Journal title :
Breast
ISSN :
0960-9776
eISSN :
1532-3080
Publisher :
Churchill Livingstone, Inc., Edinburgh, United Kingdom
Volume :
12
Issue :
2
Pages :
142-149
Peer reviewed :
Peer reviewed
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