Letter to the editor (Scientific journals)
Membrane type-1 matrix metalloproteinase and TIMP-2 in tumor angiogenesis
Sounni, Nor Eddine; Janssen, M.; Foidart, Jean-Michel et al.
2003In Matrix Biology, 22 (1), p. 55-61
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Keywords :
MT1-MMP; tumoral angiogenesis; vascular endothelial growth factor; protease inhibitors; estradiol
Abstract :
[en] The matrix metalloproteinases (MMPs) constitute a multigene family of over 23 secreted and cell-surface associated enzymes that cleave or degrade various pericellular substrates. In addition to virtually all extracellular matrix (ECM) compounds, their targets include other proteinases, chemotactic molecules, latent growth factors, growth factor-binding proteins and cell surface molecules. The MMP activity is controlled by the physiological tissue inhibitors of MMPs (TIMPs). There is much evidence that MMPs and their inhibitors play a key role during extracellular remodeling in physiological situations and in cancer progression. They have other functions that promoting tumor invasion. Indeed, they regulate early stages of tumor progression such as tumor growth and angiogenesis. Membrane type MMPs (MT-MMPs) constitute a new subset of cell surface-associated MMPs. The present review will focus on MT1-MMP which plays a major role at least, in the ECM remodeling, directly by degrading several of its components, and indirectly by activating pro-MMP2. As our knowledge on the field of MT1-MMP biology has grown, the unforeseen complexities of this enzyme and its interaction with its inhibitor TIMP-2 have emerged, often revealing unexpected mechanisms of action. (C) 2003 Elsevier Science B.V/Intemational Society of Matrix Biology. All rights reserved.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Sounni, Nor Eddine  ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Janssen, M.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Noël, Agnès ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme
Language :
English
Title :
Membrane type-1 matrix metalloproteinase and TIMP-2 in tumor angiogenesis
Publication date :
March 2003
Journal title :
Matrix Biology
ISSN :
0945-053X
eISSN :
1569-1802
Publisher :
Gustav Fischer Verlag, Stuttgart, Germany
Volume :
22
Issue :
1
Pages :
55-61
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
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