Reference : Evidence for a partial epithelial-mesenchymal transition in postnatal stages of rat a...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Life sciences : Zoology
http://hdl.handle.net/2268/123424
Evidence for a partial epithelial-mesenchymal transition in postnatal stages of rat auditory organ morphogenesis.
English
[fr] Preuve d'une transition épithelio-mésenchymateuse partielle durant la morphogenèse de l'organe de l'audition
Johnen, Nicolas mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
Francart, Marie-Emilie mailto [Université de Liège - ULg > > > GIGA - Utilisateurs machines]
Thelen, Nicolas mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
Cloes, Marie mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
Thiry, Marc mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
7-May-2012
Histochemistry & Cell Biology
Springer Science & Business Media B.V.
Yes (verified by ORBi)
International
0948-6143
1432-119X
New York
NY
[en] Epithelial-mesenchymal transition ; Cytoskeleton ; organ of Corti ; Development
[en] The epithelial-mesenchymal transition (EMT) plays a crucial role in the differentiation of many tissues and organs. So far, an EMT was not detected in the development of the auditory organ. To determine whether an EMT may play a role in the morphogenesis of the auditory organ, we studied the spatial localization of several EMT markers, the cell-cell adhesion molecules and intermediate filament cytoskeletal proteins, in epithelium of the dorsal cochlea during development of the rat Corti organ from E18 (18th embryonic day) until P25 (25th postnatal day). We examined by confocal microscopy immunolabelings on cryosections of whole cochleae with antibodies anti-cytokeratins as well as with antibodies anti-vimentin, anti-E-cadherin and anti-β-catenin. Our results showed a partial loss of E-cadherin and β-catenin and a temporary appearance of vimentin in pillar cells and Deiters between P8 and P10. These observations suggest that a partial EMT might be involved in the remodelling of the Corti organ during the postnatal stages of development in rat.
Giga-Neurosciences
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/123424
10.1007/s00418-012-0969-5
http://www.springerlink.com/content/d827862017862334/

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Johnen et al., 2012. Evidence for a partial epithelial-mesenchymal transition in postnatal stages of rat auditory organ morphogenesis.pdfPublisher postprint1.48 MBView/Open

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