Reference : Comparison of the sedative and hemodynamic effects of acepromazine and promethazine i...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/123084
Comparison of the sedative and hemodynamic effects of acepromazine and promethazine in the standing horse.
English
Pequito, Manuel [> >]
Amory, Hélène mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Médecine interne des équidés >]
Serteyn, Didier mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
Busoni, Valeria mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Imagerie médicale >]
de Moffarts, Brieuc [> >]
Sandersen, Charlotte mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés >]
2012
Journal of Equine Veterinary Science
Elsevier
32
12
1-6
Yes (verified by ORBi)
International
0737-0806
New York
NY
[en] Horse ; sedation ; acepromazine ; promethazine ; doppler echocardiography ; hemodynamics
[en] The objective of this study was to compare the sedative and peripheral hemodynamic effects of acepromazine (ACP) and promethazine (PTZ) in the standing healthy horse. Nine healthy Warmblood horses randomly received either intravenous ACP at 0.1 mg/kg or PTZ at 0.1, 0.2, and 0.3 mg/kg. A sedation score based on clinical examination was recorded, and systolic arterial blood pressure was noninvasively evaluated using a Doppler flow detector at the tail, just before and every 15 minutes until 60 minutes after drug injection. Hemodynamics of the median artery of the left forelimb was studied using Doppler ultrasonography just before and 45 minutes after injection of the drug, which allowed calculation of surface (SURF), diameter (DIAM), and circumference (CIRC) of the vessel and peak systolic velocity (PSV), end diastolic velocity (EDV), mean velocity (MV), volumetric flow (VF), and resistivity index (RI) of the blood flow. Regardless of the dose used, PTZ had lesser sedative and hypotensive effects than ACP at 0.1 mg/kg and did not induce significant variations in SURF, DIAM, CIRC, PSV, EDV, MV, VF, and RI of the studied standing horses. Conversely, the vasodilatory properties of ACP were illustrated by a significant increase in SURF, DIAM, CIRC, PSV, EDV, MV, and VF and a significant reduction of the RI. Unlike ACP, PTZ did not induce alterations on the morphology of the Doppler waveform. PTZ appears to have less sedative and peripheral vasodilator effects than ACP, thus it could be safer than ACP in patients suffering from hypotension.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/123084
also: http://hdl.handle.net/2268/150295

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