ORBi: Pequito Manuel - Comparison of the Sedative and Hemodynamic Effects of Acepromazine and Promethazine in the Standing Horse.

Reference : Comparison of the Sedative and Hemodynamic Effects of Acepromazine and Promethazine in t...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Veterinary medicine & animal health
	To cite this reference:	http://hdl.handle.net/2268/123084

Title :	Comparison of the Sedative and Hemodynamic Effects of Acepromazine and Promethazine in the Standing Horse.
Language :	English
Author, co-author :	Pequito, Manuel [ > > ]
	Amory, Hélène [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Médecine interne des équidés >]
	Serteyn, Didier [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
	Busoni, Valeria [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Imagerie médicale >]
	de Moffarts, Brieuc [ > > ]
	Sandersen, Charlotte [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés >]
Publication date :	2012
Journal title :	Journal of Equine Veterinary Science
Publisher :	Elsevier
Volume :	In Press
Audience :	International
ISSN :	0737-0806
City :	New York
Country :	NY
Keywords :	[en] acepromazine ; promethazine ; horse ; Hemodynamics ; doppler echocardiography
Abstract :	[en] The objective of this study was to compare the sedative and peripheral hemodynamic effects of acepromazine (ACP) and promethazine (PTZ) in the standing healthy horse. Nine healthy Warmblood horses randomly received either intravenous ACP at 0.1 mg/kg or PTZ at 0.1, 0.2, and 0.3 mg/kg. A sedation score based on clinical examination was recorded, and systolic arterial blood pressure was noninvasively evaluated using a Doppler flow detector at the tail, just before and every 15 minutes until 60 minutes after drug injection. Hemodynamics of the median artery of the left forelimb was studied using Doppler ultrasonography just before and 45 minutes after injection of the drug, which allowed calculation of surface (SURF), diameter (DIAM), and circumference (CIRC) of the vessel and peak systolic velocity (PSV), end diastolic velocity (EDV), mean velocity (MV), volumetric flow (VF), and resistivity index (RI) of the blood flow. Regardless of the dose used, PTZ had lesser sedative and hypotensive effects than ACP at 0.1 mg/kg and did not induce significant variations in SURF, DIAM, CIRC, PSV, EDV, MV, VF, and RI of the studied standing horses. Conversely, the vasodilatory properties of ACP were illustrated by a significant increase in SURF, DIAM, CIRC, PSV, EDV, MV, and VF and a significant reduction of the RI. Unlike ACP, PTZ did not induce alterations on the morphology of the Doppler waveform. PTZ appears to have less sedative and peripheral vasodilator effects than ACP, thus it could be safer than ACP in patients suffering from hypotension.
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/123084

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Restricted access	Pequito et al_J Equine Vet Sci_2012.pdf		Publisher postprint	185.6 kB	Request copy

All documents in ORBi are protected by a user license.

Dspace v1.5