Article (Scientific journals)
A simplified model for mitral valve dynamics.
Moorhead, K. T.; Paeme, Sabine; Chase, J. G. et al.
2013In Computer Methods and Programs in Biomedicine, 109 (2), p. 190-196
Peer Reviewed verified by ORBi
 

Files


Full Text
Moorhead_Comput Methods Programs Biomed_2011.pdf
Publisher postprint (1.24 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Located between the left atrium and the left ventricle, the mitral valve controls flow between these two cardiac chambers. Mitral valve dysfunction is a major cause of cardiac dysfunction and its dynamics are little known. A simple non-linear rotational spring model is developed and implemented to capture the dynamics of the mitral valve. A measured pressure difference curve was used as the input into the model, which represents an applied torque to the anatomical valve chords. A range of mechanical model hysteresis states were investigated to find a model that best matches reported animal data of chord movement during a heartbeat. The study is limited by the use of one dataset found in the literature due to the highly invasive nature of getting this data. However, results clearly highlight fundamental physiological issues, such as the damping and chord stiffness changing within one cardiac cycle, that would be directly represented in any mitral valve model and affect behaviour in dysfunction. Very good correlation was achieved between modeled and experimental valve angle with 1-10% absolute error in the best case, indicating good promise for future simulation of cardiac valvular dysfunction, such as mitral regurgitation or stenosis. In particular, the model provides a pathway to capturing these dysfunctions in terms of modeled stiffness or elastance that can be directly related to anatomical, structural defects and dysfunction.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Moorhead, K. T.
Paeme, Sabine ;  Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Chase, J. G.
Kolh, Philippe  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path.
Pierard, Luc ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
Hann, C. E.
Dauby, Pierre  ;  Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Desaive, Thomas  ;  Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Language :
English
Title :
A simplified model for mitral valve dynamics.
Publication date :
February 2013
Journal title :
Computer Methods and Programs in Biomedicine
ISSN :
0169-2607
eISSN :
1872-7565
Publisher :
Elsevier Scientific, Limerick, Ireland
Volume :
109
Issue :
2
Pages :
190-196
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
Available on ORBi :
since 20 May 2012

Statistics


Number of views
80 (11 by ULiège)
Number of downloads
3 (3 by ULiège)

Scopus citations®
 
3
Scopus citations®
without self-citations
1
OpenCitations
 
3

Bibliography


Similar publications



Contact ORBi