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Pharma-clinics. Le medicament du mois. Le rofecoxib (Vioxx).
Scheen, André
2000In Revue Médicale de Liège, 55 (7), p. 751-3
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Keywords :
Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal/pharmacology/therapeutic use; Arthritis, Rheumatoid/drug therapy; Biological Availability; Drug Interactions; Humans; Lactones/pharmacology/therapeutic use; Osteoarthritis/drug therapy; Sulfones; Treatment Outcome
Abstract :
[en] Rofecoxib (Vioxx, Merck Sharp & Dohme) is a potent and selective inhibitor of the COX-2 isoform of cyclooxygenase which is used as a nonsteroidal anti-inflammatory drug (NSAID). It is indicated in the symptomatic relief of pain due to osteoarthritis. The initial oral dosage of rofecoxib is 12.5 mg once daily in adults, and this dose may be increased up to a maximal dosage of 25 mg once daily if necessary. Its clinical efficacy seems to be similar to that of other NSAIDs at maximal recommended dosages, but its safety profile, especially gastrointestinal tolerance, is much better because of the COX-2 selectivity. Ongoing clinical trials are performed in patients with rheumatoid arthritis.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
Pharma-clinics. Le medicament du mois. Le rofecoxib (Vioxx).
Alternative titles :
[fr] Pharma-clinics. The drug of the month. Rofecoxib (Vioxx)
Publication date :
2000
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Hopital de Baviere, Liège, Belgium
Volume :
55
Issue :
7
Pages :
751-3
Peer reviewed :
Peer reviewed
Available on ORBi :
since 06 May 2009

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