Reference : In vivo and in vitro estrogenic activity of the antidepressant fluoxetine.
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
In vivo and in vitro estrogenic activity of the antidepressant fluoxetine.
Muller, JC [> >]
Didimo Imazaki, Pedro Henrique mailto [Université de Liège - ULg > Département des Sciences des denrées alimentaires > > >]
Boareto, AC [> > > >]
Lourenco, EL [> > > >]
Golin, M [> > > >]
Vechi, MF [> > > >]
Lombardi, NF [> > > >]
Minatovicz, BC [> > > >]
Scippo, Marie-Louise mailto [Université de Liège - ULg > Département de sciences des denrées alimentaires > Analyse des denrées alimentaires]
Martino-Andrade, AJ [> > > >]
Dalsenter, PR [> > > >]
Reproductive Toxicology
Pergamon In Cooperation With the Reproductive Toxicology Center
Yes (verified by ORBi)
[en] Recent years have seen an increase in the use of antidepressant drugs, especially fluoxetine (FLX), in sensitive populations, such as pregnant and lactating women. Although some evidence suggests a possible endocrine action of FLX, no specific studies have been performed to investigate this hypothesis. In the present study, we investigated the possible (anti)androgenic and (anti)estrogenic actions of FLX using Hershberger, uterotrophic (0.4, 1.7, and 17mg/kg), and reporter gene (7.6-129muM) assays. In the Hershberger assay, no differences were observed in androgen-dependent organ weights. However, the uterotrophic and gene reporter assays indicated a possible estrogenic action of FLX. Uterine weight increased in the 1.7 and 17mg/kg/day groups in the 3-day uterotrophic assay in immature rats. Additionally, noncytotoxic concentrations of FLX induced estrogenic responses and increased the estrogenic response of estradiol in MCF-7 breast cancer cells transfected with luciferase.
Copyright (c) 2012. Published by Elsevier Inc.

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