ORBi: Genon Sarah - Verbal learning in Alzheimer’s disease and mild cognitive impairment:fine-grained acquisition and short-delay consolidation performance and neural correlates

Reference : Verbal learning in Alzheimer’s disease and mild cognitive impairment:fine-grained acquis...


	Document type :	Scientific journals : Article
	Discipline(s) :	Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/2268/122375

Title :	Verbal learning in Alzheimer’s disease and mild cognitive impairment:fine-grained acquisition and short-delay consolidation performance and neural correlates
Language :	English
Author, co-author :	Genon, Sarah [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
	Collette, Fabienne [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Neuropsychologie >]
	Moulin, Chris [University of Leeds, UK > > > >]
	LEKEU, Françoise [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
	Bahri, Mohamed Ali [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Salmon, Eric [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
	Bastin, Christine [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Publication date :	2013
Journal title :	Neurobiology of Aging
Publisher :	Elsevier
Volume :	34
Pages :	361-373
Audience :	International
ISSN :	0197-4580
e-ISSN :	1558-1497
City :	New York
Country :	NY
Keywords :	[en] Alzheimer’s disease ; Mild cognitive impairment ; Verbal learning ; Verbal acquisition ; Short-delay consolidation ; Brain imaging
Abstract :	[en] The aim of this study was to examine correlations between acquisition and short-delay consolidation and brain metabolism at rest measured by fluorodeoxyglucose positron emission tomography (FDG-PET) in 44 Alzheimer’s disease (AD) patients, 16 patients with mild cognitive impairment (MCI) who progressed to dementia (MCI-AD), 15 MCI patients who remained stable (MCI-S, 4–8 years of follow-up), and 20 healthy older participants. Acquisition and short-delay consolidation were calculated respectively as mean gained (MG) and lost (ML) access to items of the California Verbal Learning Task. MG performance suggests that acquisition is impaired in AD patients even at predementia stage (MCI-AD). ML performance suggests that short-delay consolidation is deficient only in confirmed AD patients. Variations in acquisition performance in control participants are related to metabolic activity in the anterior parietal cortex, an area supporting task-positive attentional processes. In contrast, the acquisition deficit is related to decreased activity in the lateral temporal cortex, an area supporting semantic processes, in patients at an early stage of AD and is related to metabolic activity in the hippocampus, an area supporting associative processes, in confirmed AD patients.
Research units :	Centre de Recherches du Cyclotron - CRC
Permalink :	http://hdl.handle.net/2268/122375

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Restricted access	Manuscript_GENON_NBA_proof.doc		Author preprint	281 kB	Request copy

All documents in ORBi are protected by a user license.

Dspace v1.5