Reference : Verbal learning in Alzheimer’s disease and mild cognitive impairment:fine-grained acq...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/122375
Verbal learning in Alzheimer’s disease and mild cognitive impairment:fine-grained acquisition and short-delay consolidation performance and neural correlates
English
Genon, Sarah mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Collette, Fabienne mailto [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Neuropsychologie >]
Moulin, Chris [University of Leeds, UK > > > >]
LEKEU, Françoise mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Bahri, Mohamed Ali mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Salmon, Eric mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Bastin, Christine mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
2013
Neurobiology of Aging
Elsevier
34
361-373
Yes (verified by ORBi)
International
0197-4580
1558-1497
New York
NY
[en] Alzheimer’s disease ; Mild cognitive impairment ; Verbal learning ; Verbal acquisition ; Short-delay consolidation ; Brain imaging
[en] The aim of this study was to examine correlations between acquisition and short-delay consolidation and brain metabolism at rest measured by fluorodeoxyglucose positron emission tomography (FDG-PET) in 44 Alzheimer’s disease (AD) patients, 16 patients with mild cognitive impairment (MCI) who progressed to dementia (MCI-AD), 15 MCI patients who remained stable (MCI-S, 4–8 years of follow-up), and 20 healthy older participants. Acquisition and short-delay consolidation were calculated respectively as mean gained (MG) and lost (ML) access to items of the California Verbal Learning Task. MG performance suggests that acquisition is impaired in AD patients even at predementia stage (MCI-AD). ML performance suggests that short-delay consolidation is deficient only in confirmed AD patients. Variations in acquisition performance in control participants are related to metabolic activity in the anterior parietal cortex, an area
supporting task-positive attentional processes. In contrast, the acquisition deficit is related to decreased activity in the lateral temporal cortex, an area supporting semantic processes, in patients at an early stage of AD and is related to metabolic activity in the hippocampus, an area supporting associative processes, in confirmed AD patients.
Centre de Recherches du Cyclotron - CRC
http://hdl.handle.net/2268/122375

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