Article (Scientific journals)
Opposing Actions of Intact and N-Terminal Fragments of the Human Prolactin/Growth Hormone Family Members on Angiogenesis: An Efficient Mechanism for the Regulation of Angiogenesis
Struman, Ingrid; Bentzien, F.; Lee, H. et al.
1999In Proceedings of the National Academy of Sciences of the United States of America, 96 (4), p. 1246-51
Peer Reviewed verified by ORBi
 

Files


Full Text
Struman PNAS 99.pdf
Publisher postprint (341.41 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Angiogenesis, the process of development of a new microvasculature, is regulated by a balance of positive and negative factors. We show both in vivo and in vitro that the members of the human prolactin/growth hormone family, i.e., human prolactin, human growth hormone, human placental lactogen, and human growth hormone variant are angiogenic whereas their respective 16-kDa N-terminal fragments are antiangiogenic. The opposite actions are regulated in part via activation or inhibition of mitogen-activated protein kinase signaling pathway. In addition, the N-terminal fragments stimulate expression of type 1 plasminogen activator inhibitor whereas the intact molecules have no effect, an observation consistent with the fragments acting via separate receptors. The concept that a single molecule encodes both angiogenic and antiangiogenic peptides represents an efficient model for regulating the balance of positive and negative factors controlling angiogenesis. This hypothesis has potential physiological importance for the control of the vascular connection between the fetal and maternal circulations in the placenta, where human prolactin, human placental lactogen, and human growth hormone variant are expressed.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Struman, Ingrid  ;  Université de Liège - ULiège > Département des sciences de la vie > Biologie et génétique moléculaire
Bentzien, F.
Lee, H.
Mainfroid, V.
D'Angelo, Gisela
Goffin, Vincent
Weiner, R. I.;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Martial, Joseph 
Language :
English
Title :
Opposing Actions of Intact and N-Terminal Fragments of the Human Prolactin/Growth Hormone Family Members on Angiogenesis: An Efficient Mechanism for the Regulation of Angiogenesis
Publication date :
10 February 1999
Journal title :
Proceedings of the National Academy of Sciences of the United States of America
ISSN :
0027-8424
eISSN :
1091-6490
Publisher :
National Academy of Sciences, Washington, United States - District of Columbia
Volume :
96
Issue :
4
Pages :
1246-51
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 06 May 2009

Statistics


Number of views
61 (7 by ULiège)
Number of downloads
2 (1 by ULiège)

Scopus citations®
 
246
Scopus citations®
without self-citations
221
OpenCitations
 
182

Bibliography


Similar publications



Contact ORBi