Reference : Solid lipid microparticles as a sustained release system for pulmonary drug delivery
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/12204
Solid lipid microparticles as a sustained release system for pulmonary drug delivery
English
Jaspart, Séverine [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique et magistrale >]
Bertholet, Pascal [> > > >]
Piel, Géraldine mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique et magistrale >]
Dogné, Jean-Michel [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Delattre, Luc mailto [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Evrard, Brigitte mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique >]
Jan-2007
European Journal of Pharmaceutics & Biopharmaceutics
Elsevier Science Bv
65
1
47-56
Yes (verified by ORBi)
International
0939-6411
Amsterdam
[en] solid lipid microparticles ; pulmonary drug delivery ; sustained release ; salbutamol acetonide ; experimental design
[en] The controlled release of drugs for pulmonary, delivery is a research field which has been so far rather unexploited but is currently becoming increasingly attractive. The introduction part of this research article first details the potential advantages of solid lipid microparticles (SLMs) as drug carrier compared to liposomes and polymeric microspheres. The aim of this work is to use SLMs to impart a sustained release profile to a model drug, salbutamol acetonide (SA). SA was synthesized from salbutamol in order to increase the lipophilicity of this molecule and thereby to increase its incorporation efficiency into SLMs. SA-loaded SLMs were then produced by a hot emulsion technique followed by high-shear homogenisation and the manufacturing parameters were optimized using the experimental design methodology in order to reach a suitable particle size for pulmonary administration. Scanning electron micrographs showed that SLMs are spherical, have a smooth surface and that SA crystallises outside of the particles when the drug loading is higher than 20%. This was confirmed by X-ray diffraction. SA in vitro release study from SLMs showed that the release rate increased with SA loading but remained in every case lower than the dissolution rate of pure SA. (c) 2006 Elsevier B.V. All rights reserved.
Researchers
http://hdl.handle.net/2268/12204
10.1016/j.ejpb.2006.07.006

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