Reference : Physicochemical properties of pH-controlled polyion complex (PIC) micelles of poly(acryl...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/121670
Physicochemical properties of pH-controlled polyion complex (PIC) micelles of poly(acrylic acid)-based double hydrophilic block copolymers and various polyamines
English
Warnant, Jérôme [Institut Charles Gerhardt ( Montpellier, France) and University of Liège (ULg) > Department of Chemistry (Liège) > Center for Education and Research on Macromolecules (CERM, Liège) > >]
Marcotte, N. [Institut Charles Gerhardt, Montpellier, France > > > >]
Reboul, J. [Institut Charles Gerhardt, Montpellier, France > > > >]
Layrac, G. [Institut Charles Gerhardt, Montpellier, France > > > >]
Aqil, Abdelhafid mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Lerner, D. A. [Institut Charles Gerhardt, Montpellier, France > > > >]
Gérardin, C. [Institut Charles Gerhardt, Montpellier, France > > > >]
May-2012
Analytical and Bioanalytical Chemistry
Springer Science & Business Media B.V.
403
1395-1404
Yes (verified by ORBi)
International
1618-2642
1618-2650
Berlin
Germany
[en] self-assembly in solution ; micelle
[en] The physicochemical properties of polyion complex (PIC) micelles were investigated in order to characterize the cores constituted of electrostatic complexes of two oppositely charged polyelectrolytes. The pH-sensitive micelles were obtained with double hydrophilic block copolymers containing a poly(acrylic acid) block linked to a modified poly(ethylene oxide) block and various polyamines (polylysine, linear and branched polyethyleneimine, polyvinylpyridine, and polyallylamine). The pH range of micellization in which both components are ionized was determined for each polyamine. The resulting PIC micelles were characterized using dynamic light scattering and smallangle X-ray scattering experiments (SAXS). The PIC micelles presented a core–corona nanostructure with variable polymer density contrasts between the core and the corona, as revealed by the analysis of the SAXS curves. It was shown that PIC micelle cores constituted by polyacrylate chains and polyamines were more or less dense depending on the nature of the polyamine. It was also determined that the density of the cores of the PIC micelles depended strongly on the nature of the polyamine. These homogeneous cores were surrounded by a large hairy corona of hydrated polyethylene oxide block chains. Auramine O (AO) was successfully entrapped in the PIC micelles, and its fluorescence properties were used to get more insight on the core properties. Fluorescence data confirmed that the cores of such micelles are quite compact and that their microviscosity depended on the nature of the polyamine. The results obtained on these core–shell micelles allow contemplating a wide range of applications in which the AO probe would be replaced by various cationic drugs or other similarly charged species to form drug nanocarriers or new functional nanodevices.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; The European Network Functional Advanced Materials and Engineering "FAME"
Researchers
http://hdl.handle.net/2268/121670
10.1007/s00216-012-5947-1
http://www.springerlink.com/content/35574381505n5249/fulltext.pdf

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