|Reference : Effects of Acute Injection of Methylprednisolone in Man on Immunological and Non-Immu...|
|Scientific journals : Article|
|Human health sciences : Cardiovascular & respiratory systems|
|Effects of Acute Injection of Methylprednisolone in Man on Immunological and Non-Immunological Histamine Release from Leucocytes and Its Potentiation by Interleukin-3|
|Louis, Renaud [Université de Liège - ULg > Département des sciences cliniques > Pneumologie - Allergologie]|
|Bury, Thierry [Université de Liège - ULg > Département des sciences de la motricité > Physiologie humaine et physiologie de l'effort physique]|
|Corhay, Jean-Louis [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]|
|Radermecker, Maurice [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]|
|Clinical & Experimental Allergy : Journal of the British Society for Allergy & Clinical Immunology|
|Yes (verified by ORBi)|
|[en] We investigated the effects of intravenous injection of methylprednisolone (MPR) compared with placebo (saline) on ex vivo leucocytic histamine release in eight healthy volunteers. All subjects received in a randomized and a single-blind manner the placebo and MPR, 20 mg and 125 mg, each injection given in 2 week intervals. On each occasion blood samples were taken just before and 24 h after the intravenous injection to determine circulating leucocyte counts and leucocytic histamine release induced by anti-IgE (1/2000) and FMP (Formyl-Methionyl-Phenylalanine) (10(-5) M) and its modulation by IL-3 (2 ng/ml). MPR 20 mg and 125 mg significantly increased circulating leucocyte counts (P < 0.05 and P < 0.001 respectively) but decreased leucocytic histamine content (P < 0.05 and P < 0.001 respectively) by 24 h. Placebo had no effect. As for circulating basophils, after 24 h they were decreased by 125 mg MPR (P < 0.05) but increased by 20 mg (P < 0.05). Anti-IgE-induced HR was significantly inhibited by 125 mg MPR (P < 0.05) but not by 20 mg MPR or by the placebo. In contrast, neither MPR (20 mg and 125 mg) nor placebo significantly reduced FMP-induced HR. The strong potentiation by IL-3 of HR evoked by anti-IgE and FMP at baseline (P < 0.001) persisted 24 h after injection of MPR or placebo (P < 0.001 except P < 0.05 for anti-IgE-induced HR after 125 mg MPR).(ABSTRACT TRUNCATED AT 250 WORDS)|
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