Article (Scientific journals)
Serum osteocalcin and CTX-MMP concentration in young exercising thoroughbred racehorses
Carstanjen, B.; Amory, Hélène; Sulon, Joseph et al.
2005In Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine, 52 (3), p. 114-120
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Keywords :
bone metabolism; hose; CTX-MMP; exercise; training
Abstract :
[en] Bone responds to exercise with changes in bone (re-)modelling, which might be monitored non-invasively with biochemical bone markers. The aim of this study was to evaluate the influence of exercise on serum osteocalcin and serum carboxy-terminal cross-linked telopeptide of type I collagen generated by matrix metalloproteinases (CTX-MMP) concentration in young racehorses. Seventy-one 2 to 4-year-old Thoroughbreds were included in this prospective infield study. Blood sampling was performed six times (i.e. six sampling cycles) during a 9-month period. Serum samples were analysed with commercial osteocalcin and CTX-MMP radioimmunoassays. Two-year-old racehorses had higher serum osteocalcin and CTX-MMP values than 3-year-old horses. Gender and training amplitude did not significantly influence serum osteocalcin and CTX-MMP values. Two-year-old horses showed an increase in osteocalcin values between cycles 2 and 3 and an increase in serum CTX-MMP values between cycles 1 and 2. Serum osteocalcin and CTX-MMP concentrations decreased between cycles 4 and 5, and 5 and 6. Three-year-old horses showed an increase in serum osteocalcin levels between cycles 3 and 4 and an increase in serum CTX-MMP concentrations between cycles 1 and 2, and 3 and 4. Serum osteocalcin levels decreased between cycles 5 and 6, whereas serum CTX-MMP levels decreased between cycles 4 and 5, and 5 and 6. Two- and three-year-old horses showed a decreased osteocalcin/CTX-MMP ratio between cycles 1 and 2. Moreover, 2-year-old horses showed an increase in the osteocalcin/CTX-MMP ratio between cycles 2 and 3. Sore shin formation did not significantly influence serum osteocalcin and CTX-MMP values. Serum osteocalcin and CTX-MMP are promising bone markers for monitoring exercise induced changes in equine bone metabolism.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Carstanjen, B.
Amory, Hélène ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Médecine interne des équidés
Sulon, Joseph ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Hars, O.
Remy, Benoît ;  Université de Liège - ULiège > GIGA-Management : Plate-forme transgénique
Langlois, P.
Lepage, O.M.
Language :
English
Title :
Serum osteocalcin and CTX-MMP concentration in young exercising thoroughbred racehorses
Alternative titles :
[en] Serum osteocalcin and CTX-MMP concentration in young exercising thoroughbred racehorses
Publication date :
April 2005
Journal title :
Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine
ISSN :
0931-184X
eISSN :
1439-0442
Publisher :
Blackwell Verlag Gmbh, Berlin, Germany
Volume :
52
Issue :
3
Pages :
114-120
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 May 2012

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