|Reference : Obesite: aspects therapeutiques.|
|Scientific journals : Article|
|Human health sciences : Pharmacy, pharmacology & toxicology|
Human health sciences : Endocrinology, metabolism & nutrition
|Obesite: aspects therapeutiques.|
|[en] Obesity: therapeutic aspects|
|Scheen, André [Université de Liège - ULg > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale >]|
|Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique|
|Académie Royale de Médecine de Belgique|
|471-9; discussion 480-2|
|Yes (verified by ORBi)|
|[en] Humans ; Life Style ; Obesity/rehabilitation/therapy ; Patient Education as Topic|
|[en] Obesity is now recognized as a chronic disease. Its treatment implies a prolonged negative energy balance, by reducing caloric intake and/or increasing energy expenditure. In practice, three therapeutic approaches can be considered: 1) life-style modifications, combining well-balanced hypocaloric diet and regular physical exercise, the key-issue in obesity management; 2) in case of failure and as adjunct treatment, anti-obesity drugs, especially orlistat, an intestinal lipase inhibitor, and sibutramine, a central appetite regulator; and 3) in patients with extreme refractory obesity, surgical procedures consisting of gastric restriction (gastroplasty) or intestinal bypass. Anti-obesity treatments must be evaluated in the long run, in terms of efficacy/safety ratio, upon criteria of weight loss, reduction in associated risk factors, improvement of quality of life and, if possible, reduction of morbidity and mortality.|
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