Reference : Self-appraisal and medial prefrontal activation in early stage Alzheimer’s disease
Scientific congresses and symposiums : Paper published in a book
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/121176
Self-appraisal and medial prefrontal activation in early stage Alzheimer’s disease
English
Genon, Sarah mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Collette, Fabienne mailto [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Neuropsychologie >]
Angel, Lucie mailto [ > > ]
Salmon, Eric mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Bastin, Christine mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
10-May-2012
Proceedings of the 1st Joint Meeting of the Belgian Association for Psychological Sciences (BAPS, Belgium) and Sociedad Espanola de Psicologia Experimental (SEPEX, Spain)
52
Yes
International
Belgian Association for Psychological Science (BAPS, Belgium) & Sociedad Espanola de Psicologia Experimental (SEPEX, Spain)
10-11 mai 2012
BAPS-SEPEX
Liège
Belgique
[en] self ; fMRI ; Alzheimer's disease
[en] Introduction

Self-referential processing in healthy subjects is related to activation within cortical midline structures, such as the medial prefrontal cortex (MPFC) and the posterior cingulate cortex (Northoff et al., 2006). The structures are known to be altered in Alzheimer’s disease (AD; Buckner et al., 2008). However, little is known about their engagement during self-referential processing in AD patients.

Methods

Twenty-two mild AD patients and 22 healthy controls (HC) were administered a self-appraisal task in an fMRI experimentation. The participants saw adjectives and had to indicate if the trait describes them (Self-condition; SC) or the King Albert II/the Queen Fabiola (Other-condition; OC). We examined differences between groups (HC>AD and AD>HC) and a conjunction analysis examined brain activations that were common to both groups during the self-appraisal process (p<.001 uncorrected with a-priori hypotheses).

Results

No region was found to be significantly more activated during self-appraisal in HC than in AD and vice versa. The VMPFC was the only region commonly activated in AD and HC during self-appraisal process (Punc<.001).

Conclusions

The study demonstrates that AD patients at early stages of the disease may still engage the MPFC during self-referential processing (compared to a well-known but not close “other”) as HC do.

References:

Northoff, G., Heinzel, A., de Greck, M., Bermpohl, F., Dobrowolny, H. & Pankseepp, J. (2006). Self-referential processing in our brain-A meta-analysis of imaging studies on the self. NeuroImage, 31, 440-457.

Buckner, R.L., Andrews-Hanna, J.R., Schacter, D.L. (2008). The brain’s default network: anatomy, function and relevance to disease. Annals of the New York Academy of Sciences 1124, 1-38.
Centre de Recherches du Cyclotron - CRC
http://hdl.handle.net/2268/121176

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