Reference : Human papillomavirus DNA strongly correlates with a poorer prognosis in oral cavity carc...
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/121000
Human papillomavirus DNA strongly correlates with a poorer prognosis in oral cavity carcinoma.
English
Duray, A [> > > >]
Descamps, G [> > > >]
Decaestecker, C [> > > >]
Remmelink, M [> > > >]
Sirtaine, N [> > > >]
Lechien, J [> > > >]
Ernoux-Neufcoeur, P [> > > >]
BLETARD, Noëlla mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique]
Somja, Joan mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques]
Depuydt, CE [> > > >]
Delvenne, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques]
Saussez, S [> > > >]
2012
Laryngoscope
Lippincott Williams & Wilkins
122
7
1558-65
Yes (verified by ORBi)
International
0023-852X
1531-4995
Philadelphia
PA
[en] OBJECTIVES/HYPOTHESIS: The prevalence of human papillomavirus (HPV) in a clinical series of 162 patients with oral squamous cell carcinoma (OSCC) was studied. Furthermore, we analyzed the correlation between the immunohistochemical expression of p16, p53, epidermal growth factor receptor (EGFR), and HPV status to predict survival in OSCC patients. STUDY DESIGN: Retrospective study. METHODS: Paraffin-embedded samples from OSCC patients (n = 162) were evaluated for the presence of HPV DNA using both GP5+/GP6+ consensus polymerase chain reaction (PCR) and type-specific E6/E7 PCR to detect HPV types 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, and 68. Immunohistochemical staining for p16, p53, and EGFR was also performed. RESULTS: The type-specific E6/E7 PCR demonstrated that 65 of the 147 OSCC patients (44%) presented with high-risk (hr) HPV types and that 38 of the 147 OSCC patients (26%) presented with low-risk (lr) HPV types. Comparable p53 and EGFR expression levels were observed in the hr HPV+ group (41.5% p53+, 92% EGFR+) and the lr HPV+ group (57% p53+, 92% EGFR+). Conversely, a slight increase in the proportion of p16+ tumors was observed in the hr HPV+ group (65%) compared with the lr HPV+ group (44%). In regard to patient outcome, the presence of HPV was correlated with a worse prognosis (P = .007). CONCLUSIONS: A high prevalence of hr and lr HPV infections was detected in the OSCC patients included in the study. Moreover, hr HPV positivity was correlated with a decreased 5-year disease-free survival rate compared with HPV- and lr HPV+.
http://hdl.handle.net/2268/121000
10.1002/lary.23298
Copyright (c) 2012 The American Laryngological, Rhinological, and Otological Society, Inc.

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Duray Laryngoscope 2012.pdfPublisher postprint1.4 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.