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| Reference : Anti-UVC Irradiation and Metal Chelation Properties of 6-Benzoyl-5,7-dihydroxy-4-phenyl-... |
| Scientific journals : Article | |||
| Physical, chemical, mathematical & earth Sciences : Chemistry Life sciences : Biochemistry, biophysics & molecular biology Human health sciences : Pharmacy, pharmacology & toxicology | |||
| http://hdl.handle.net/2268/120981 | |||
| Anti-UVC Irradiation and Metal Chelation Properties of 6-Benzoyl-5,7-dihydroxy-4-phenyl-chromen-2-one: An Implication for Anti-Cataract Agent | |
| English | |
Huang, Yi-Shiang  [Academia Sinica, Taiwan > Institute of Biological Chemistry > > >] | |
| 21-Oct-2011 | |
| International Journal of Molecular Sciences | |
| Molecular Diversity Preservation International (MDPI) | |
| 12 | |
| 7059-7076 | |
| 1422-0067 | |
| Basel | |
| Switzerland | |
| [en] irradiation ; anti-cataract ; coumarin ; γ-crystallin ; iron-chelation | |
| [en] Coumarin derivative 1, 5,7-dihydroxy-6-(3-methyl-1-butyryl)-4-phenyl-chromen- 2-one, has been reported to possess radical scavenging activity and DNA protection. We have synthesized a series of coumarins with structural modifications at positions C4, C5, C6 and C7 and evaluated them for their anti-UVC properties. Coumarin 7, 6-benzoyl-5,6-dihydroxy-4-phenyl-chromen-2-one, was found to have the most potent activity in protecting porcine γ-crystallin against UVC insults. Results of fluorescence assays indicated that compound 7 was capable of decreasing the loss of intensity while lens crystallins and DNA PUC19 were irradiated with UVC. Presence of compound 7 decreased hydroxyl radical levels determined by probe 1b and the free iron concentrations determined by Ferrozine reagent. The chelation assay showed that compound 7 was chelated to metal via 6-CO and 5-OH on the benzopyrone ring. The observed protective effects of compound 7 towards crystallins from insults of UVC and free radicals may be due to its iron-chelating activity and its peak absorption at 254 nm. | |
| National Science Council (NSC98-2313-B-038-002-MY3) and Academia Sinica, Taipei, Taiwan | |
| http://hdl.handle.net/2268/120981 | |
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3211027/ |
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