Reference : Immunosuppression in Pancreas Transplantation The Euro SPK Trials and Beyond
Scientific journals : Article
Human health sciences : Surgery
http://hdl.handle.net/2268/12071
Immunosuppression in Pancreas Transplantation The Euro SPK Trials and Beyond
English
Malaise, J. [> >]
De Roover, Arnaud mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Squifflet, Jean-Paul mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Land, W. [> >]
europe SPK study group [> >]
2008
Acta Chirurgica Belgica
Acta Medica Belgica
108
673-678
Yes (verified by ORBi)
National
0001-5458
Bruxelles
Belgique
[en] Pancreas Transplantation ; immunosuppression
[en] The Immunosuppression in Pancreas Transplantation was historically based on the fact that the pancreas is an
extremely immunogenic organ. Quadruple drug therapy with polyclonal or monoclonal antibodies induction was the
mainstay therapy since the introduction of Cyclosporine A.
In the modern era of Immunosuppression, Mycophenolate Mofetil replaced Azathioprine while Tacrolimus-another potent
calcineurin inhibitor-had-and still has-a difficult challenge to replaced Cyclosporine A, due to its potential diabetogenic
effect. Thanks to the first two EuroSPK studies which prospectively tried to answer several questions in that field.
But, the future challenge will be in understanding the impact of innate immunity and ischemic reperfusion injuries on
the long term graft function. Hopefully, new drugs will be available and tested to block unspecific deleterious reactions
to attenuate the proinflammatory response. It will be the aim of the third Euro SPK Stud
Professionals ; Students ; General public
http://hdl.handle.net/2268/12071
also: http://hdl.handle.net/2268/10106

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