Article (Scientific journals)
Immunosuppression in Pancreas Transplantation The Euro SPK Trials and Beyond
Malaise, J.; De Roover, Arnaud; Squifflet, Jean-Paul et al.
2008In Acta Chirurgica Belgica, 108, p. 673-678
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Keywords :
Pancreas Transplantation; immunosuppression
Abstract :
[en] The Immunosuppression in Pancreas Transplantation was historically based on the fact that the pancreas is an extremely immunogenic organ. Quadruple drug therapy with polyclonal or monoclonal antibodies induction was the mainstay therapy since the introduction of Cyclosporine A. In the modern era of Immunosuppression, Mycophenolate Mofetil replaced Azathioprine while Tacrolimus-another potent calcineurin inhibitor-had-and still has-a difficult challenge to replaced Cyclosporine A, due to its potential diabetogenic effect. Thanks to the first two EuroSPK studies which prospectively tried to answer several questions in that field. But, the future challenge will be in understanding the impact of innate immunity and ischemic reperfusion injuries on the long term graft function. Hopefully, new drugs will be available and tested to block unspecific deleterious reactions to attenuate the proinflammatory response. It will be the aim of the third Euro SPK Stud
Disciplines :
Surgery
Author, co-author :
Malaise, J.
De Roover, Arnaud ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Squifflet, Jean-Paul ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Land, W.
europe SPK study group
Language :
English
Title :
Immunosuppression in Pancreas Transplantation The Euro SPK Trials and Beyond
Publication date :
2008
Journal title :
Acta Chirurgica Belgica
ISSN :
1784-3421
eISSN :
2577-0160
Publisher :
Acta Medica Belgica, Bruxelles, Belgium
Volume :
108
Pages :
673-678
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 May 2009

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