Article (Scientific journals)
Obesity and liver disease.
Scheen, André; Luyckx, Françoise
2002In Best Practice and Research. Clinical Endocrinology and Metabolism, 16 (4), p. 703-16
Peer Reviewed verified by ORBi
 

Files


Full Text
obesity and liver disease.pdf.pdf
Author postprint (269.88 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Cytokines; Diabetes Mellitus, Type 2/complications; Fatty Acids, Nonesterified; Fatty Liver/diagnosis/etiology/therapy; Humans; Insulin Resistance; Leptin; Obesity/complications; Oxidative Stress; Prognosis; Weight Loss
Abstract :
[en] Non-alcoholic steatohepatitis (NASH) is a disease of emerging identity and importance. It is frequently associated with obesity, especially visceral fat, and is intimately related to fatty liver and markers of the insulin resistance syndrome. Both the prevalence and the severity of liver steatosis are related to body mass index, waist circumference, hyperinsulinaemia, hypertriglyceridaemia and impaired glucose tolerance or type 2 diabetes. The identification of obese patients who may progress from steatosis to NASH and from NASH to fibrosis/cirrhosis is an important clinical challenge. Substantial weight loss is accompanied by a marked attenuation of insulin resistance and related metabolic syndrome and, concomitantly, by a remarkable regression of liver steatosis in most patients, although increased inflammation may be detected in some subjects. Thus, NASH may be considered as another disease of affluence, as is the insulin resistance syndrome, and perhaps being part of it, especially in obese patients.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Luyckx, Françoise ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Language :
English
Title :
Obesity and liver disease.
Publication date :
2002
Journal title :
Best Practice and Research. Clinical Endocrinology and Metabolism
eISSN :
1878-1594
Publisher :
Bailliere Tindall And Cassell, United Kingdom
Volume :
16
Issue :
4
Pages :
703-16
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 May 2009

Statistics


Number of views
160 (3 by ULiège)
Number of downloads
1514 (2 by ULiège)

Scopus citations®
 
107
Scopus citations®
without self-citations
100
OpenCitations
 
86

Bibliography


Similar publications



Contact ORBi