The kallikrein-kinin system: Current and future pharmacological targets

[en] The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and mainly tissue and plasma kallikreins. The pharmacologically active kinins, which are often considered as either proinflammatory or cardioprotective, are implicated in many physiological and pathological processes. The interest of the various components of this multi-protein system is explained in part by the multiplicity of its pharmacological activities, mediated not only by kinins and their receptors, but also by their precursors and their activators and the metal lopeptidases and the antiproteases that limit their activities. The regulation of this system by serpins and the wide distribution of the different constituents add to the complexity of this system, as well as its multiple relationships with other important metabolic pathways such as the renin-angiotensin, coagulation, or complement pathways. The purpose of this review is to summarize the main properties of this kallikrein-kinin system and to address the multiple pharmacological interventions that modulate the functions of this system, restraining its proinflammatory effects or potentiating its cardiovascular properties.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Moreau, Marie Eve

Garbacki, Nancy ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Protéines et glycoprot. de matr.extracell. et membran.basal.

Molinaro, Guiseppe

Brown, Nancy J

Marceau, François

Adam, Albert

Language :

English

Title :

The kallikrein-kinin system: Current and future pharmacological targets

Publication date :

September 2005

Journal title :

Journal of Pharmacological Sciences

ISSN :

1347-8613

eISSN :

1347-8648

Publisher :

Japanese Pharmacological Soc, Kyoto, Japan

Volume :

Issue :

Pages :

6-38

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 May 2009

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370

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347

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319

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