ORBi: Garbacki Nancy - Matrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling?

Reference : Matrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/2268/12062

Title :	Matrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling?
Language :	English
Author, co-author :	Garbacki, Nancy [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Protéines et glycoprot. de matr.extracell. et membran.basal. >]
	Di Valentin, Emmanuel [Université de Liège - ULg > > GIGA-R : Virologie - Immunologie >]
	Piette, Jacques [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Virologie - Immunologie - GIGA-Research >]
	Cataldo, Didier [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path. >]
	Crahay, Céline [ > > ]
	Colige, Alain [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Protéines et glycoprot. de matr.extracell. et membran.basal. >]
Publication date :	2009
Journal title :	Pulmonary Pharmacology & Therapeutics
Publisher :	Academic Press
Volume :	22
Issue/season :	4
Pages :	267-278
Audience :	International
ISSN :	1094-5539
City :	London
Country :	United Kingdom
Keywords :	[en] siRNA delivery ; RNA interference; ; MMP-12 ; Asthma ; COPD ; Therapy
Abstract :	[en] Among the large matrix metalloproteinases (MMPs) family, MMP-12, also referred to as macrophage elastase, plays a significant role in chronic pulmonary pathologies characterized by an intense tissue remodeling such as asthma and COPD. This review will summarize knowledge about MMP-12 structure, functions and mechanisms of activation and regulation, including potential MMP-12 modulation by microRNA. As MMP-12 is involved in many tissue remodeling diseases, efforts have been made to develop specific synthetic inhibitors. However, at this time, very few chemical inhibitors have proved to be efficient and specific to a particular MMP. The relevance of silencing MMP-12 by RNA interference is highlighted. The specificity of this approach using siRNA or shRNA and the strategies to deliver these molecules in the lung are discussed.
Permalink :	http://hdl.handle.net/2268/12062
DOI :	10.1016/j.pupt.2009.03.001

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