Article (Scientific journals)
Trophoblast Invasion and Placentation: Molecular Mechanisms and Regulation
van den Brule, F.; Berndt, Sarah; Simon, N. et al.
2005In Chemical Immunology and Allergy, 88, p. 163-80
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Abstract :
[en] Trophoblast invasion is a key process during human placentation. This event constitutes the basis of the conversion of the uterine spiral arteries, a process which allows an adequate vascular connection between the intervillous space and the maternal blood flow. Trophoblast invasion is transient, with stringent spatial and temporal control. Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is associated with decreased, shallow trophoblastic invasion. In this article, we review the molecular mechanisms of trophoblast invasion, and its mechanisms of regulation. Insights into the etiopathogenesis of preeclampsia will also be detailed.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
van den Brule, F.
Berndt, Sarah ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Simon, N.
Coulon, C.
Le Goarant, J.
Munaut, Carine  ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Noël, Agnès ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme
Frankenne, Francis
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Language :
English
Title :
Trophoblast Invasion and Placentation: Molecular Mechanisms and Regulation
Publication date :
2005
Journal title :
Chemical Immunology and Allergy
ISSN :
1660-2242
Publisher :
Karger, Switzerland
Volume :
88
Pages :
163-80
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 May 2009

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