Reference : Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for ...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Oncology
http://hdl.handle.net/2268/12045
Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth
English
Bajou, Khalid mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie et génétique moléculaire >]
Maillard, Catherine [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Jost, M. [> > > >]
Lijnen, R. H. [> > > >]
Gils, A. [> > > >]
Declerck, P. [> > > >]
Carmeliet, P. [> > > >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
9-Sep-2004
Oncogene
Nature Publishing Group
23
41
6986-6990
Yes (verified by ORBi)
International
0950-9232
1476-5594
Basingstoke
United Kingdom
[en] PAI-1 ; cancer invasion ; tumoral angiogenesis ; serine protease ; protease inhibitor
[en] Plasminogen activator inhibitor type 1 (PAI-1) plays a key role in tumor progression and is believed to control proteolytic activity and cell migration during angiogenesis. We report here that host PAI-1, at physiological concentration, promotes in vivo tumor invasion and angiogenesis. In sharp contrast, inhibition of tumor vascularization was observed when PAI-1 was produced at supraphysiologic levels, either by host cells (transgenic mice overexpressing PAI-1) or by tumor cells (after transfection with murine PAI-1 cDNA). This study provides for the first time in vivo evidence for a dose-dependent effect of PAI-1 on tumor angiogenesis. Of great interest is the finding that PAI-1 produced by tumor cells, even at high concentration, did not overcome the absence of PAI-1 in the host, emphasizing the importance of the cellular source of PAI-1.
http://hdl.handle.net/2268/12045
10.1038/sj.onc.1207859

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Bajou K Oncogene 2004.pdf.pdfAuthor postprint544.4 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.